Nonphotic entrainment of the human circadian pacemaker.

Nonphotic entrainment of the human circadian pacemaker.
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人类昼夜节律起搏器的非光夹带。

DOI:
10.1152/ajpregu.1998.274.4.r991
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发表时间:
1998
期刊:
The American journal of physiology
影响因子:
--
通讯作者:
Czeisler,CA
Czeisler,CA
中科院分区:
--
文献类型:
--
作者:
Klerman,EB;Rimmer,DW;Dijk,DJ;Kronauer,RE;Rizzo3rd,JF;Czeisler,CA

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在单细胞藻类和人类等多种生物体中,光是介导昼夜生物钟夹带的主要刺激。一些完全失明的人出现夹带到24小时的一天的报告表明,非光刺激也可能是有效的昼夜同步在人类中,虽然非光刺激可能是相对较弱的同步,因为昼夜节律的许多完全失明的人“自由运行”,即使他们保持24小时的活动休息时间表。为了研究夹带的nonphotic同步,我们研究了内源性昼夜褪黑激素和核心体温的节奏15个完全失明的科目谁缺乏有意识的光感知,并没有表现出抑制血浆褪黑激素在眼睛明亮的光暴露。这15个盲人中有9个能够保持同步的24小时一天,虽然往往在一个非典型的相位角夹带。非光刺激也同步的内源性昼夜节律的一个完全失明的个人非24小时的时间表,而生活在恒定的近黑暗。我们的结论是,非光刺激可以夹带人类的昼夜节律起搏器在一些人缺乏眼睛昼夜光感受。
In organisms as diverse as single-celled algae and humans, light is the primary stimulus mediating entrainment of the circadian biological clock. Reports that some totally blind individuals appear entrained to the 24-h day have suggested that nonphotic stimuli may also be effective circadian synchronizers in humans, although the nonphotic stimuli are probably comparatively weak synchronizers, because the circadian rhythms of many totally blind individuals “free run” even when they maintain a 24-h activity-rest schedule. To investigate entrainment by nonphotic synchronizers, we studied the endogenous circadian melatonin and core body temperature rhythms of 15 totally blind subjects who lacked conscious light perception and exhibited no suppression of plasma melatonin in response to ocular bright-light exposure. Nine of these fifteen blind individuals were able to maintain synchronization to the 24-h day, albeit often at an atypical phase angle of entrainment. Nonphotic stimuli also synchronized the endogenous circadian rhythms of a totally blind individual to a non-24-h schedule while living in constant near darkness. We conclude that nonphotic stimuli can entrain the human circadian pacemaker in some individuals lacking ocular circadian photoreception.
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