Metabolic reprogramming, oxidative stress, and pulmonary hypertension.
Metabolic reprogramming, oxidative stress, and pulmonary hypertension.
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代谢重编程、氧化应激和肺动脉高压。
DOI：
10.1016/j.redox.2023.102797
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发表时间：
2023-08
期刊：
影响因子：
11.4
通讯作者：
Black, Stephen M.
中科院分区：
文献类型：
--
作者：
Pokharel, Marissa D.;Marciano, David P.;Fu, Panfeng;Franco, Maria Clara;Unwalla, Hoshang;Tieu, Kim;Fineman, Jeffrey R.;Wang, Ting;Black, Stephen M.
线粒体是细胞代谢、生长和功能所必需的高度动态的细胞器。越来越清楚的是，内皮细胞功能障碍显著有助于各种肺部疾病（包括肺动脉高压（PAH））的发病机制和血管重塑，并且线粒体是这种功能障碍的中心。我们越是发现线粒体在肺血管疾病中的作用，就越明显地发现多个途径参与其中。为了实现有效的治疗，我们必须了解这些途径是如何失调的，以便能够进行治疗干预。我们知道一氧化氮信号传导、葡萄糖代谢、脂肪酸氧化和TCA循环在PAH中异常，沿着线粒体膜电位、增殖和凋亡的改变。然而，这些途径在PAH中的特征不完全，特别是在内皮细胞中，突出了进一步研究的迫切需要。这篇综述总结了目前已知的关于线粒体代谢如何促进内皮细胞的代谢转变，从而诱导PAH期间的血管重塑。
Mitochondria are highly dynamic organelles essential for cell metabolism, growth, and function. It is becoming increasingly clear that endothelial cell dysfunction significantly contributes to the pathogenesis and vascular remodeling of various lung diseases, including pulmonary arterial hypertension (PAH), and that mitochondria are at the center of this dysfunction. The more we uncover the role mitochondria play in pulmonary vascular disease, the more apparent it becomes that multiple pathways are involved. To achieve effective treatments, we must understand how these pathways are dysregulated to be able to intervene therapeutically. We know that nitric oxide signaling, glucose metabolism, fatty acid oxidation, and the TCA cycle are abnormal in PAH, along with alterations in the mitochondrial membrane potential, proliferation, and apoptosis. However, these pathways are incompletely characterized in PAH, especially in endothelial cells, highlighting the urgent need for further research. This review summarizes what is currently known about how mitochondrial metabolism facilitates a metabolic shift in endothelial cells that induces vascular remodeling during PAH.
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影响因子：
5.6
作者：
Andruska A;Spiekerkoetter E
通讯作者：
Spiekerkoetter E
影响因子：
1.7
作者：
Carraway, MS;Piantadosi, CA;Huang, YCT
通讯作者：
Huang, YCT
影响因子：
2.5
作者：
AMEMIYA, T
通讯作者：
AMEMIYA, T
影响因子：
2.9
作者：
Nisbet RE;Sutliff RL;Hart CM
通讯作者：
Hart CM
DOI：
10.1097/pcc.0000000000001275
发表时间：
2017-10
期刊：
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
影响因子：
--
作者：
Black SM;Field-Ridley A;Sharma S;Kumar S;Keller RL;Kameny R;Maltepe E;Datar SA;Fineman JR
通讯作者：
Fineman JR