E-cadherin expression in postnatal Schwann cells is regulated by the cAMP-dependent protein kinase a pathway.
E-cadherin expression in postnatal Schwann cells is regulated by the cAMP-dependent protein kinase a pathway.
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依赖CAMP依赖性蛋白激酶A途径在产后雪旺氏细胞中的E-钙粘蛋白表达受到调节。
DOI：
10.1002/glia.20716
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发表时间：
2008-11-15
期刊：
影响因子：
6.2
通讯作者：
Kim, Haesun A.
中科院分区：
文献类型：
--
作者：
Crawford, Audrita T.;Desai, Darshan;Gokina, Pradeepa;Basak, Sayantani;Kim, Haesun A.
E-cadherin在周围神经系统中的表达是一个高度调节的过程，其在出生后与髓鞘化雪旺细胞谱系的发育一致。作为自体型连接的主要成分，E-钙粘蛋白在维持非致密髓鞘区域的结构完整性方面起着重要作用。在体内，出生后雪旺细胞中E-cadherin的出现伴随着N-cadherin的消失，这表明在雪旺细胞发育过程中两种cadherin相互调节。调节雪旺细胞钙粘蛋白开关的分子信号尚不清楚。使用神经元-雪旺细胞共培养系统，在这里，我们表明，E-cadherin的表达诱导的轴突膜上的组件。我们还表明，轴突效应是通过cAMP依赖性蛋白激酶A（cAMP-PKA）激活的雪旺细胞介导的：1）抑制cAMP-PKA阻断轴突诱导的E-钙粘蛋白的表达和2）cAMP升高雪旺细胞足以诱导E-钙粘蛋白的表达。此外，cAMP依赖的E-钙粘蛋白的表达促进相邻的许旺细胞膜之间的接触，这表明其在髓鞘形成过程中的自身型连接形成的作用。此外，cAMP诱导的E-钙粘蛋白表达伴随着N-钙粘蛋白表达的抑制。因此，我们建议，轴突依赖性激活cAMP-PKA作为一个信号，促进钙粘蛋白开关在出生后发育的雪旺细胞。
Expression of E-cadherin in the peripheral nervous system is a highly regulated process that appears postnatally in concert with the development of myelinating Schwann cell lineage. As a major component of autotypic junctions, E-cadherin plays an important role in maintaining the structural integrity of non-compact myelin regions. In vivo, the appearance of E-cadherin in postnatal Schwann cell is accompanied by the disappearance of N-cadherin, suggesting reciprocal regulation of the two cadherins during Schwann cell development. The molecular signal that regulates the cadherin switch in Schwann cell is unclear. Using a neuron-Schwann cell co-culture system, here we show that E-cadherin expression is induced by components on the axonal membrane. We also show that the axonal effect is mediated through cAMP-dependent protein kinase A (cAMP-PKA) activation in the Schwann cell: 1) inhibition of cAMP-PKA blocks axon-induced E-cadherin expression and 2) cAMP elevation in the Schwann cell is sufficient to induce E-cadherin expression. In addition, cAMP-dependent E-cadherin expression is promoted by contact between adjacent Schwann cell membranes, suggesting its role in autotypic junction formation during myelination. Furthermore, cAMP-induced E-cadherin expression is accompanied by suppression of N-cadherin expression. Therefore, we propose that axon-dependent activation of cAMP-PKA serves as a signal that promotes cadherin switch during postnatal development of Schwann cells.
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影响因子：
16.2
作者：
Howe, CL;Valletta, JS;Mobley, WC
通讯作者：
Mobley, WC
影响因子：
21.3
作者：
Batlle, E;Sancho, E;de Herreros, AG
通讯作者：
de Herreros, AG
影响因子：
16.2
作者：
LEMKE, G;LAMAR, E;PATTERSON, J
通讯作者：
PATTERSON, J
新型的E-钙粘蛋白介导的外周神经：Schwann细胞结构的粘附稳定在自动型粘附连接处。
影响因子：
7.8
作者：
Fannon, A M;Sherman, D L;Ilyina-Gragerova, G;Brophy, P J;Friedrich, V L Jr;Colman, D R
通讯作者：
Colman, D R
DOI：
10.1007/bf01188399
发表时间：
1990-06-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
GOULD, RM;MATTINGLY, G
通讯作者：
MATTINGLY, G