Modulation of Inflammatory Responses by Wnt/β-Catenin Signaling in Dendritic Cells: A Novel Immunotherapy Target for Autoimmunity and Cancer.
Modulation of Inflammatory Responses by Wnt/β-Catenin Signaling in Dendritic Cells: A Novel Immunotherapy Target for Autoimmunity and Cancer.
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树突状细胞中Wnt/β-连环蛋白信号通路对炎症反应的调节：自身免疫性疾病和癌症的新型免疫治疗靶点
DOI：
10.3389/fimmu.2016.00460
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发表时间：
2016
影响因子：
7.3
通讯作者：
Manicassamy S
中科院分区：
文献类型：
--
作者：
Suryawanshi A;Tadagavadi RK;Swafford D;Manicassamy S
The Wnt/β-catenin pathway is an evolutionarily conserved signaling pathway critical for several biological processes. An aberrant Wnt/β-catenin signaling is linked to several human diseases. Emerging studies have highlighted the regulatory role of the Wnt/β-catenin signaling pathway in normal physiological processes of parenchymal and hematopoietic cells. Recent studies have shown that the activation of Wnt/β-catenin pathway in dendritic cells (DCs) play a critical role in mucosal tolerance and suppression of chronic autoimmune pathologies. Alternatively, tumors activate Wnt/β-catenin pathway in DCs to induce immune tolerance and thereby evade antitumor immunity through suppression of effector T cell responses and promotion of regulatory T cell responses. Here, we review our work and current understanding of how Wnt/β-catenin signaling in DCs shapes the immune response in cancer and autoimmunity and discuss how Wnt/β-catenin pathway can be targeted for successful therapeutic interventions in various human diseases.
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影响因子：
11.2
作者：
Hong Y;Manoharan I;Suryawanshi A;Majumdar T;Angus-Hill ML;Koni PA;Manicassamy B;Mellor AL;Munn DH;Manicassamy S
通讯作者：
Manicassamy S
影响因子：
10.1
作者：
Holtzhausen A;Zhao F;Evans KS;Tsutsui M;Orabona C;Tyler DS;Hanks BA
通讯作者：
Hanks BA
DOI：
10.1083/jcb.153.5.1049
发表时间：
2001-05-28
期刊：
The Journal of cell biology
影响因子：
--
作者：
Gottardi CJ;Wong E;Gumbiner BM
通讯作者：
Gumbiner BM
DOI：
10.1038/nri3477
发表时间：
2013-08
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.3
作者：
Hoffman, J;Kuhnert, F;Kuo, CJ
通讯作者：
Kuo, CJ