Use of computed tomography-derived body composition to determine the prognosis of patients with primary liver cancer treated with immune checkpoint inhibitors: a retrospective cohort study.
Use of computed tomography-derived body composition to determine the prognosis of patients with primary liver cancer treated with immune checkpoint inhibitors: a retrospective cohort study.
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DOI：
10.1186/s12885-022-09823-7
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发表时间：
2022-07-06
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影响因子：
3.8
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中科院分区：
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免疫检查点抑制剂(ICIS)已经被成功地用于治疗原发性肝癌(PLC)；然而，识别与治疗益处相关的可改变的患者因素是具有挑战性的。众所周知，肥胖与ICI治疗后存活率的增加有关；然而，身体成分(肌肉、脂肪)和预后之间的关系尚不清楚。本研究的目的是评估石蜡包埋与CT衍生脂肪含量及ICIS预后之间的关系。对172例肝癌患者进行回顾性队列研究，用CT测量骨骼肌指数(SMI)、骨骼肌密度、内脏脂肪组织指数、皮下脂肪组织指数、总脂肪组织指数(TATI)和内脏/皮下脂肪组织面积比。此外，我们还分析了身体成分对患者预后的影响。采用多因素COX回归分析筛选影响因素。在七种身体成分中，低SMI(骨质疏松症)和低TATI与较差的临床结果显著相关。多因素分析显示，骨质疏松症(危险比[HR]为5.39；95%可信区间[CI]为1.74-16.74；p = 为0.004)是总生存期(OS)的显著预测因素。Kaplan-Meier曲线显示石棺减少和TATI是OS的显著预测因子。体重指数与生存结果无关。在接受ICIS治疗的PLC患者中，骨质疏松症和脂肪组织含量似乎独立地与生存率降低有关。网上版载有补充材料，可在10.1186/s12885-022-09823-7查阅。
Immune checkpoint inhibitors (ICIs) have been used to successfully treat primary liver cancer (PLC); however, identifying modifiable patient factors associated with therapeutic benefits is challenging. Obesity is known to be associated with increased survival after ICI treatment; however, the relationship between body composition (muscle, fat) and outcomes is unclear. This study aimed to evaluate the association between sarcopenia and CT-derived fat content and the prognosis of ICIs for the treatment of PLC. In this retrospective cohort study of 172 patients with PLC, we measured the skeletal muscle index (SMI), skeletal muscle density, visceral adipose tissue index, subcutaneous adipose tissue index, total adipose tissue index (TATI), and visceral-to-subcutaneous adipose tissue area ratio using CT. In addition, we analyzed the impact of body composition on the prognosis of the patients. Multivariate Cox regression analysis was used to screen for influencing factors. Among the seven body composition components, low SMI (sarcopenia) and low TATI were significantly associated with poor clinical outcomes. Multivariate analysis revealed that sarcopenia (hazard ratio [HR], 5.39; 95% confidence interval [CI], 1.74–16.74; p = 0.004) was a significant predictor of overall survival (OS). Kaplan–Meier curves showed that sarcopenia and TATI were significant predictors of OS. Body mass index was not associated with survival outcomes. Sarcopenia and fat tissue content appear to be independently associated with reduced survival rates in patients with PLC treated with ICIs. The online version contains supplementary material available at 10.1186/s12885-022-09823-7.
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影响因子：
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作者：
Wang, Jia-Ren;Li, Rui-Ning;Xiao, Lu-Shan
通讯作者：
Xiao, Lu-Shan
影响因子：
--
作者：
Xiao, Lu-Shan;Li, Qi-Mei;Liu, Li
通讯作者：
Liu, Li
DOI：
10.1111/apha.12224
发表时间：
2014-03
期刊：
Acta physiologica (Oxford, England)
影响因子：
--
作者：
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通讯作者：
Mazurak VC
影响因子：
28.4
作者：
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通讯作者：
Chen, Wendy Y.
影响因子：
6
作者：
Antonelli, Giulio;Gigante, Elia;Marignani, Massimo
通讯作者：
Marignani, Massimo