Reactive Oxygen Species: A Key Constituent in Cancer Survival.
Reactive Oxygen Species: A Key Constituent in Cancer Survival.
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DOI：
10.1177/1177271918755391
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发表时间：
2018
影响因子：
3.8
通讯作者：
Malla R
中科院分区：
文献类型：
--
作者：
Kumari S;Badana AK;G MM;G S;Malla R
恶性肿瘤是一种发病率高、死亡率高、预后差的异质性疾病。活性氧（ROS）水平升高、氧化还原平衡改变和氧化还原信号转导失调是癌症进展和耐药的常见标志。线粒体主要参与氧化磷酸化过程中ROS的产生。由于高代谢活性、细胞信号传导、过氧化物酶体活性、线粒体功能障碍、癌基因活化以及氧化酶、环加氧酶、脂氧合酶和胸苷磷酸化酶的酶活性增加，在癌细胞中检测到ROS水平升高。细胞通过发展一个巨大的抗氧化系统，包括过氧化氢酶，超氧化物歧化酶和谷胱甘肽过氧化物酶来维持细胞内的稳态。除此之外，这些酶还存在重要的抗氧化剂谷胱甘肽和转录因子Nrf2，它们有助于平衡氧化应激。活性氧介导的信号传导途径激活原癌信号传导，从而缓解癌症进展、血管生成和存活。同时，为了维持ROS稳态和逃避癌细胞死亡，抗氧化能力水平的增加与癌细胞相关。本文综述了ROS在肿瘤生存途径中的作用以及靶向参与肿瘤发生发展的ROS信号的重要性，这是肿瘤治疗的新策略。
Cancer is one of the major heterogeneous disease with high morbidity and mortality with poor prognosis. Elevated levels of reactive oxygen species (ROS), alteration in redox balance, and deregulated redox signaling are common hallmarks of cancer progression and resistance to treatment. Mitochondria contribute mainly in the generation of ROS during oxidative phosphorylation. Elevated levels of ROS have been detected in cancers cells due to high metabolic activity, cellular signaling, peroxisomal activity, mitochondrial dysfunction, activation of oncogene, and increased enzymatic activity of oxidases, cyclooxygenases, lipoxygenases, and thymidine phosphorylases. Cells maintain intracellular homeostasis by developing an immense antioxidant system including catalase, superoxide dismutase, and glutathione peroxidase. Besides these enzymes exist an important antioxidant glutathione and transcription factor Nrf2 which contribute in balancing oxidative stress. Reactive oxygen species–mediated signaling pathways activate pro-oncogenic signaling which eases in cancer progression, angiogenesis, and survival. Concomitantly, to maintain ROS homeostasis and evade cancer cell death, an increased level of antioxidant capacity is associated with cancer cells. This review focuses the role of ROS in cancer survival pathways and importance of targeting the ROS signal involved in cancer development, which is a new strategy in cancer treatment.
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DOI：
10.1126/science.1211485
发表时间：
2011-12-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Anastasiou D;Poulogiannis G;Asara JM;Boxer MB;Jiang JK;Shen M;Bellinger G;Sasaki AT;Locasale JW;Auld DS;Thomas CJ;Vander Heiden MG;Cantley LC
通讯作者：
Cantley LC
影响因子：
4.8
作者：
Bienert, Gerd P.;Moller, Anders L. B.;Jahn, Thomas P.
通讯作者：
Jahn, Thomas P.
影响因子：
10.5
作者：
Itoh, K;Wakabayashi, N;Yamamoto, M
通讯作者：
Yamamoto, M
影响因子：
4.1
作者：
Han, D;Williams, E;Cadenas, E
通讯作者：
Cadenas, E
影响因子：
1.3
作者：
Kumar, Anil;Pant, Mohan C.;Khandelwal, Shashi
通讯作者：
Khandelwal, Shashi