Genetic Case-Control Study for Eight Polymorphisms Associated with Rheumatoid Arthritis.
Genetic Case-Control Study for Eight Polymorphisms Associated with Rheumatoid Arthritis.
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DOI：
10.1371/journal.pone.0131960
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Shaker OG
中科院分区：
文献类型：
--
作者：
Saad MN;Mabrouk MS;Eldeib AM;Shaker OG
Rheumatoid arthritis (RA) is an autoimmune disease which has a significant socio-economic impact. The aim of the current study was to investigate eight candidate RA susceptibility loci to identify the associated variants in Egyptian population. Eight single nucleotide polymorphisms (SNPs) (MTHFR—C677T and A1298C, TGFβ1 T869C, TNFB A252G, and VDR—ApaI, BsmI, FokI, and TaqI) were tested by genotyping patients with RA (n = 105) and unrelated controls (n = 80). Associations were tested using multiplicative, dominant, recessive, and co-dominant models. Also, the linkage disequilibrium (LD) between the VDR SNPs was measured to detect any indirect association. By comparing RA patients with controls (TNFB, BsmI, and TaqI), SNPs were associated with RA using all models. MTHFR C677T was associated with RA using all models except the recessive model. TGFβ1 and MTHFR A1298C were associated with RA using the dominant and the co-dominant models. The recessive model represented the association for ApaI variant. There were no significant differences for FokI and the presence of RA disease by the used models examination. For LD results, There was a high D′ value between BsmI and FokI (D′ = 0.91), but the r2 value between them was poor. All the studied SNPs may contribute to the susceptibility of RA disease in Egyptian population except for FokI SNP.
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影响因子：
27.4
作者：
Hughes, L. B.;Beasley, T. M.;Bridges, S. L., Jr.
通讯作者：
Bridges, S. L., Jr.
DOI：
10.1046/j.1365-2370.2001.00233.x
发表时间：
2001-02-01
期刊：
EUROPEAN JOURNAL OF IMMUNOGENETICS
影响因子：
--
作者：
Garcia-Lozano, JR;Gonzalez-Escribano, MF;Núñez-Roldán, A
通讯作者：
Núñez-Roldán, A
影响因子：
2.1
作者：
Kim, SY;Han, SW;Kang, YM
通讯作者：
Kang, YM
影响因子：
4.4
作者：
Inanir, Ahmet;Yigit, Serbulent;Kismali, Gorkem
通讯作者：
Kismali, Gorkem
DOI：
10.4137/cmamd.s6941
发表时间：
2011-01-01
影响因子：
2.6
作者：
Al-Rayes, Hannan;Al-Swailem, Ramiz;Tariq, Mohammad
通讯作者：
Tariq, Mohammad