Osteocytes and mechanical loading: The Wnt connection.
Osteocytes and mechanical loading: The Wnt connection.
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DOI：
10.1111/ocr.12282
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发表时间：
2019-05
影响因子：
3.1
通讯作者：
Robling, Alexander G.
中科院分区：
文献类型：
--
作者：
Bullock, Whitney A.;Pavalko, Frederick M.;Robling, Alexander G.
骨骼能够适应它所经历的机械力。正畸牙齿移动利用细胞和组织水平的机械转导特性来实现牙列的对准和重组。然而，尽管已经确定了几种机制，但允许骨吸收和形成的作用机制对施加在牙齿上的负荷的反应还不完全清楚。骨细胞中的WNT/LRP5信号通路是调节骨组织对负荷反应的关键途径。许多小鼠模型中存在针对Wnt信号相关基因的敲入、敲除和转基因/过表达等位基因，这表明Wnt/LRP5及其在骨细胞中的定位对于适当的骨机械转导是必要的。牙槽骨富含骨细胞，是一种高度机械反应的组织，在该组织中已识别出典型的Wnt信号级联的成分。随着基于WNT的药物在未来几年开始临床应用，摆在面前的一个主要挑战将是对WNT在牙槽骨中的生物学有更全面的了解，以便改善/加速牙齿移动成为可能。
Bone adapts to the mechanical forces that it experiences. Orthodontic tooth movement harnesses the cell- and tissue-level properties of mechanotransduction to achieve alignment and reorganization of the dentition. However, the mechanisms of action that permit bone resorption and formation in response to loads placed on the teeth are incompletely elucidated, though several mechanisms have been identified. Wnt/Lrp5 signaling in osteocytes is a key pathway that modulates bone tissue’s response to load. Numerous mouse models that harbor knock-in, knockout, and transgenic/overexpression alleles targeting genes related to Wnt signaling point to the necessity of Wnt/Lrp5, and its localization to osteocytes, for proper mechanotransduction in bone. Alveolar bone is rich in osteocytes and is a highly mechanoresponsive tissue in which components of the canonical Wnt signaling cascade have been identified. As Wnt-based agents become clinically available in the next several years, the a major challenge that lies ahead will be to gain a more complete understanding of Wnt biology in alveolar bone so that improved/expedited tooth movement becomes a possibility.
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影响因子：
64.5
作者：
Gong, YQ;Slee, RB;Warman, ML
通讯作者：
Warman, ML
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
4.1
作者：
Zhao, Liming;Shim, Joon W.;Dodge, Todd R.;Robling, Alexander G.;Yokota, Hiroki
通讯作者：
Yokota, Hiroki
影响因子：
2
作者：
Ohazama, Atsushi;Porntaveetus, Thantrira;Ota, Masato S.;Herz, Joachim;Sharpe, Paul T.
通讯作者：
Sharpe, Paul T.
DOI：
10.1007/s00018-012-1209-9
发表时间：
2013-09
期刊：
Cellular and molecular life sciences : CMLS
影响因子：
--
作者：
Zong Y;Jin R
通讯作者：
Jin R