Human papillomavirus vaccine to prevent cervical intraepithelial neoplasia in Japan: A nationwide case-control study.
Human papillomavirus vaccine to prevent cervical intraepithelial neoplasia in Japan: A nationwide case-control study.
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DOI：
10.1111/cas.14682
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发表时间：
2021-03
期刊：
影响因子：
5.7
通讯作者：
Sobue T
中科院分区：
文献类型：
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作者：
Ikeda S;Ueda Y;Hara M;Yagi A;Kitamura T;Kitamura Y;Konishi H;Kakizoe T;Sekine M;Enomoto T;Sobue T
子宫颈癌仍然是全世界妇女最常见的癌症之一，可以通过接种疫苗预防。日本厚生劳动省于2013年暂停了常规人乳头瘤病毒（HPV）疫苗的积极推荐，原因是慢性疼痛和运动障碍等各种症状。这项全国性病例对照研究于2013年4月至2017年3月针对20 - 24岁接受宫颈筛查的女性。我们比较了细胞学异常和正常的人之间的HPV疫苗接种暴露。根据组织学检查结果对异常细胞学进行分类，并使用条件logistic回归模型计算上述终点和疫苗接种暴露的比值比（OR）和95%置信区间（CI），并使用公式（1 - OR）× 100估计疫苗有效性。在日本的31个城市中，共有2483例病例和12296例对照（一对五匹配）符合条件。组织学异常病例中，CIN 1（包括异型增生）797例（32.1%），CIN 2 165例（6.7%），CIN 3 44例（1.8%），鳞状细胞癌（SCC）8例（0.3%）。HPV疫苗接种与未接种相比，细胞学异常、CIN 1+、CIN 2+和CIN 3+与对照相比的OR为0.42（95% CI，0.34 - 0.50），0.42（95%CI，0.31 - 0.58），0.25（95% CI，0.12 - 0.54）和0.19（95% CI，0.03 - 1.15），相当于疫苗有效性分别为58.5%、57.9%、74.8%和80.9%。8名患者患有SCC，无一人接种疫苗。这项在日本进行的全国性病例对照研究表明，与未接种HPV疫苗的女性相比，接种HPV疫苗的女性出现异常细胞学和宫颈上皮内瘤变的风险大幅降低。这项在日本进行的全国性病例对照研究显示，与未接受HPV疫苗接种的女性相比，接受HPV疫苗接种的女性的异常细胞学和CIN风险大幅降低。
Cervical cancer remains among the most common cancers in women worldwide and can be prevented by vaccination. The Ministry of Health, Labour and Welfare of Japan suspended active recommendation of regular human papillomavirus (HPV) vaccines in 2013 because of various symptoms including chronic pain and motor impairment. This nationwide case‐control study from April 2013 to March 2017 targeted women aged 20‐24 years old at cervical screening. We compared HPV vaccination exposure between those with abnormal and normal cytology. Abnormal cytology was classified based on the results of histological test and we calculated the odds ratio (OR) and 95% confidence interval (CI) of the above endpoints and vaccination exposure using the conditional logistic regression model and estimated vaccine effectiveness using the formula (1 – OR) × 100. A total of 2483 cases and 12 296 controls (one‐to‐five matching) were eligible in 31 municipalities in Japan. The distribution of histological abnormalities among cases was 797 CIN1 (including dysplasia) (32.1%), 165 CIN2 (6.7%), 44 CIN3 (1.8%), and eight squamous cell carcinoma (SCC) (0.3%). The OR of HPV vaccination compared with no vaccination for abnormal cytology, CIN1+, CIN2+, and CIN3+ versus controls was 0.42 (95% CI, 0.34‐0.50), 0.42 (95% CI, 0.31‐0.58), 0.25 (95% CI, 0.12‐0.54), and 0.19 (95% CI, 0.03‐1.15), respectively, equating to a vaccine effectiveness of 58.5%, 57.9%, 74.8%, and 80.9%, respectively. Eight patients had SCC, none was vaccinated. This nationwide case‐control study in Japan demonstrated a substantial risk reduction in abnormal cytology and CIN among women who did versus those who did not receive HPV vaccination. This nationwide case‐control study with official vaccination records in Japan demonstrated a substantial risk reduction in abnormal cytology and CIN among women who did versus those who did not receive HPV vaccination.
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DOI：
10.2185/jrm.2986
发表时间：
2019-05-01
期刊：
Journal of rural medicine : JRM
影响因子：
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作者：
Karube, Akihiro;Saito, Fumiko;Nagao, Daisuke
通讯作者：
Nagao, Daisuke
影响因子：
1.6
作者：
Tanaka, Hidenori;Shirasawa, Hiromitsu;Terada, Yukihiro
通讯作者：
Terada, Yukihiro
影响因子：
6.4
作者：
Kudo, Risa;Yamaguchi, Manako;Enomoto, Takayuki
通讯作者：
Enomoto, Takayuki
DOI：
10.1093/cid/ciw354
发表时间：
2016-08-15
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Garland SM;Kjaer SK;Muñoz N;Block SL;Brown DR;DiNubile MJ;Lindsay BR;Kuter BJ;Perez G;Dominiak-Felden G;Saah AJ;Drury R;Das R;Velicer C
通讯作者：
Velicer C
影响因子：
10.3
作者：
Munoz, Nubia;Kjaer, Susanne K.;Haupt, Richard M.
通讯作者：
Haupt, Richard M.