Reward-related behavioral paradigms for addiction research in the mouse: performance of common inbred strains.
Reward-related behavioral paradigms for addiction research in the mouse: performance of common inbred strains.
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DOI：
10.1371/journal.pone.0015536
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发表时间：
2011-01-10
期刊：
影响因子：
3.7
通讯作者：
Holmes A
中科院分区：
文献类型：
--
作者：
Lederle L;Weber S;Wright T;Feyder M;Brigman JL;Crombag HS;Saksida LM;Bussey TJ;Holmes A
小鼠已经成为研究复杂行为的分子和遗传基础以及模拟神经精神疾病状态的独特有价值的物种。虽然奖励相关行为的有效和可靠的临床前试验对于理解成瘾相关过程至关重要，并且已经在大鼠和灵长类动物中开发和表征了各种行为程序，但在小鼠中使用基于操作的成瘾相关行为范式的研究相对较少。在这里，我们描述了三个主要的奖励相关的范例的C57 BL/6 J近交系小鼠品系的性能，并复制相同的程序在其他两个常用的近交系（DBA/2 J，BALB/cJ）。我们研究了巴甫洛夫工具转移（PIT）通过测量与食物奖励相关的听觉线索的能力，以促进工具（杠杆按下）的反应。在一个单独的实验中，我们评估了一个简单的刺激奖励工具行为的收购和灭绝的触摸屏为基础的任务。然后，在连续暴露于与奖励、短暂奖励和CR暴露相关的线索（条件反射，CR）或短暂奖励暴露后连续CR暴露后，检查这种行为的恢复。第三个范例检查的敏感性，一个工具（杠杆按下）贬值的食物奖励（结果不敏感的探针，习惯性行为）的反应，通过反复配对不适。结果表明，C57 BL/6 J小鼠表现出稳健的PIT，以及明显的消退和恢复，但对肿瘤细胞贬值不敏感。DBA/2 J小鼠表现出良好的PIT和（奖励）恢复，但熄灭缓慢，没有表现出更大的贬值或显着的CR恢复。BALB/cJ小鼠也表现出良好的PIT、消退和恢复，并在贬值后保留了工具反应，但与其他品系不同，表现出减少的巴甫洛夫接近行为（食物杂志头条目）。总的来说，这些试验提供了强大的范例，为未来的研究，使用小鼠阐明神经，分子和遗传因素的奖励相关的行为成瘾的研究。
The mouse has emerged as a uniquely valuable species for studying the molecular and genetic basis of complex behaviors and modeling neuropsychiatric disease states. While valid and reliable preclinical assays for reward-related behaviors are critical to understanding addiction-related processes, and various behavioral procedures have been developed and characterized in rats and primates, there have been relatively few studies using operant-based addiction-relevant behavioral paradigms in the mouse. Here we describe the performance of the C57BL/6J inbred mouse strain on three major reward-related paradigms, and replicate the same procedures in two other commonly used inbred strains (DBA/2J, BALB/cJ). We examined Pavlovian-instrumental transfer (PIT) by measuring the ability of an auditory cue associated with food reward to promote an instrumental (lever press) response. In a separate experiment, we assessed the acquisition and extinction of a simple stimulus-reward instrumental behavior on a touchscreen-based task. Reinstatement of this behavior was then examined following either continuous exposure to cues (conditioned reinforcers, CRs) associated with reward, brief reward and CR exposure, or brief reward exposure followed by continuous CR exposure. The third paradigm examined sensitivity of an instrumental (lever press) response to devaluation of food reward (a probe for outcome insensitive, habitual behavior) by repeated pairing with malaise. Results showed that C57BL/6J mice displayed robust PIT, as well as clear extinction and reinstatement, but were insensitive to reinforcer devaluation. DBA/2J mice showed good PIT and (rewarded) reinstatement, but were slow to extinguish and did not show reinforcer devaluation or significant CR-reinstatement. BALB/cJ mice also displayed good PIT, extinction and reinstatement, and retained instrumental responding following devaluation, but, unlike the other strains, demonstrated reduced Pavlovian approach behavior (food magazine head entries). Overall, these assays provide robust paradigms for future studies using the mouse to elucidate the neural, molecular and genetic factors underpinning reward-related behaviors relevant to addiction research.
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DOI：
10.1523/jneurosci.4904-07.2008
发表时间：
2008-08-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hefner K;Whittle N;Juhasz J;Norcross M;Karlsson RM;Saksida LM;Bussey TJ;Singewald N;Holmes A
通讯作者：
Holmes A
影响因子：
2.7
作者：
Boyce-Rustay, Janel M.;Janos, Alicia L.;Holmes, Andrew
通讯作者：
Holmes, Andrew
DOI：
10.1080/14640748308400912
发表时间：
1983-01-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION B-COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
DICKINSON, A;NICHOLAS, DJ;ADAMS, CD
通讯作者：
ADAMS, CD
DOI：
10.1037/0097-7403.21.3.203
发表时间：
1995-07-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES
影响因子：
--
作者：
BALLEINE, BW;GARNER, C;DICKINSON, A
通讯作者：
DICKINSON, A
DOI：
10.1038/npp.2008.182
发表时间：
2009-05
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
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