TOX defines a conserved subfamily of HMG-box proteins.
TOX defines a conserved subfamily of HMG-box proteins.
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DOI：
10.1186/1471-2164-4-13
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发表时间：
2003-04-02
期刊：
影响因子：
4.4
通讯作者：
Kaye J
中科院分区：
文献类型：
--
作者：
O'Flaherty E;Kaye J
HMG-box蛋白是一个庞大而多样的结构因子超家族，它们共享一个或多个序列和结构相关的DNA结合域拷贝。这些蛋白质可以通过弯曲和解开DNA来改变染色质结构。HMG-box蛋白可分为两个亚家族，基于它们是否以序列依赖或序列独立的方式识别DNA。我们最近发现了一个参与T细胞发育的HMG-box蛋白，命名为TOX，它在人类和小鼠中高度保守。我们在这里表明，基于序列比对，TOX最适合于序列无关的HMG-box家族。另外三种人类和小鼠的预测蛋白与TOX共享一个共同的HMG-box结构域，以及其他特征。与TOX相比，编码这些额外家庭成员之一的基因具有独特但重叠的组织表达模式。此外，我们还在河豚和蚊子中鉴定了预测TOX HMG-box亚家族成员的编码基因。我们已经确定了一个新的HMG-box蛋白亚家族，它与最近描述的TOX蛋白有关。人类和小鼠中TOX蛋白家族的高度保守性质以及家族成员之间表达模式的差异表明单个蛋白的功能不重叠。此外，我们的数据表明，HMG-box结构域的TOX亚型首先出现在无脊椎动物中，在早期脊椎动物中被复制，并可能在哺乳动物物种中发挥新的功能。
HMG-box proteins are a large and diverse superfamily of architectural factors that share one or more copies of a sequence- and structurally-related DNA binding domain. These proteins can modify chromatin structure by bending and unwinding DNA. HMG-box proteins can be divided into two subfamilies based on whether they recognize DNA in a sequence-dependent or sequence-independent manner. We recently identified an HMG-box protein involved in T cell development, designated TOX, which is highly conserved in humans and mice. We show here that based on sequence alignment, TOX best fits into the sequence-independent HMG-box family. Three other human and murine predicted proteins are identified that share a common HMG-box domain with TOX, as well as other features. The gene encoding one of these additional family members has a distinct but overlapping pattern of tissue expression when compared to TOX. In addition, we identify genes encoding predicted TOX HMG-box subfamily members in pufferfish and mosquito. We have identified a novel subfamily of HMG-box proteins that is related to the recently described TOX protein. The highly conserved nature of the TOX family of proteins in humans and mice and differences in the pattern of expression between family members suggest non-overlapping functions of individual proteins. In addition, our data suggest that the TOX subtype of HMG-box domain first appeared in invertebrates, was duplicated in early vertebrates and likely took on new functions in mammalian species.
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影响因子：
11.4
作者：
Allain, FHT;Yen, YM;Feigon, J
通讯作者：
Feigon, J
DOI：
10.1073/pnas.94.15.7698
发表时间：
1997-07-22
影响因子：
11.1
作者：
Gilbert, W;deSouza, SJ;Long, MY
通讯作者：
Long, MY
影响因子：
64.8
作者：
Alizadeh, AA;Eisen, MB;Staudt, LM
通讯作者：
Staudt, LM
影响因子：
64.5
作者：
LEARNED, RM;LEARNED, TK;TJIAN, RT
通讯作者：
TJIAN, RT
影响因子：
64.8
作者：
LOVE, JJ;LI, XA;WRIGHT, PE
通讯作者：
WRIGHT, PE