Channel-length dependence of particle diffusivity in confinement.
Channel-length dependence of particle diffusivity in confinement.
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DOI：
10.1039/d1sm00289a
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发表时间：
2021-05-26
期刊：
影响因子：
3.4
通讯作者：
Keyser UF
中科院分区：
文献类型：
--
作者：
Tottori S;Misiunas K;Tshitoyan V;Keyser UF
了解通道中颗粒和大分子的扩散行为对于生物和合成系统（例如通道蛋白、纳米孔和纳米流体）至关重要。尽管理论和数值模型提出了一些解决方案，但这些模型尚未得到直接实验测量的完全支持。在这里，我们证明了有限开放通道中粒子的实验扩散系数总是高于基于无限长通道的传统理论模型的预测。通过结合微流体实验、数值模拟和分析模型，我们表明扩散系数不仅取决于半径比，还取决于通道长度、邻近储层的边界条件和介质的可压缩性。当允许流过通道时，有限开放通道中颗粒的扩散系数总是高于基于无限长通道的常规理论模型的预测。
Understanding the diffusive behavior of particles and large molecules in channels is of fundamental importance in biological and synthetic systems, such as channel proteins, nanopores, and nanofluidics. Although theoretical and numerical modelings have suggested some solutions, these models have not been fully supported with direct experimental measurements. Here, we demonstrate that experimental diffusion coefficients of particles in finite open-ended channels are always higher than the prediction based on the conventional theoretical model of infinitely long channels. By combining microfluidic experiments, numerical simulations, and analytical modeling, we show that diffusion coefficients are dependent not only on the radius ratio but also on the channel length, the boundary conditions of the neighboring reservoirs, and the compressibility of the medium. The diffusion coefficients of particles in finite open-ended channels are always higher than the prediction based on the conventional theoretical model of infinitely long channels when the flow is permitted through the channels.
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影响因子：
4.6
作者：
WEISSBERG, HL
通讯作者：
WEISSBERG, HL
影响因子：
10.8
作者：
Angeli, Elena;Volpe, Andrea;Fanzio, Paola;Repetto, Luca;Firpo, Giuseppe;Guida, Patrizia;Lo Savio, Roberto;Wanunu, Meni;Valbusa, Ugo
通讯作者：
Valbusa, Ugo
影响因子：
2.3
作者：
Dahiya, Ravinder;Gottardi, Gloria;Laidani, Nadhira
通讯作者：
Laidani, Nadhira
DOI：
10.1073/pnas.1707815114
发表时间：
2017-09-05
影响因子：
11.1
作者：
Yang, Xiang;Liu, Chang;Zhang, H. P.
通讯作者：
Zhang, H. P.
影响因子：
3.7
作者：
DAGAN, Z;WEINBAUM, S;PFEFFER, R
通讯作者：
PFEFFER, R