Therapeutic hypothermia for stroke: Unique challenges at the bedside.
Therapeutic hypothermia for stroke: Unique challenges at the bedside.
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DOI：
10.3389/fneur.2022.951586
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发表时间：
2022
影响因子：
3.4
通讯作者：
Yenari, Midori A.
中科院分区：
文献类型：
--
作者：
You, Je Sung;Kim, Jong Youl;Yenari, Midori A.
关键词：
治疗性低温已显示出作为改善几种神经系统疾病的神经结局的一种手段的前景。在临床水平上，它已被证明可以改善心脏骤停昏迷幸存者和新生儿缺氧缺血性脑病的结局，但尚未在中风中令人信服地证明。虽然许多临床前研究已经显示了中风模型的益处，但将其转化为临床水平已被证明具有挑战性。主要障碍包括冷却典型中风患者，这些患者清醒并自主呼吸，但通常有显著的合并症。围绕这些问题的解决方案包括选择性大脑冷却和冷却到较低的深度或避免体温过高。本文综述了低温治疗的保护机制，以及选择性脑冷却和轻微降低脑温的神经保护作用的最新进展。低温治疗中风已被证明是可行的，但尚未被明确证明有效。在这方面显然还有许多工作要做。
Therapeutic hypothermia has shown promise as a means to improving neurological outcomes at several neurological conditions. At the clinical level, it has been shown to improve outcomes in comatose survivors of cardiac arrest and in neonatal hypoxic ischemic encephalopathy, but has yet to be convincingly demonstrated in stroke. While numerous preclinical studies have shown benefit in stroke models, translating this to the clinical level has proven challenging. Major obstacles include cooling patients with typical stroke who are awake and breathing spontaneously but often have significant comorbidities. Solutions around these problems include selective brain cooling and cooling to lesser depths or avoiding hyperthermia. This review will cover the mechanisms of protection by therapeutic hypothermia, as well as recent progress made in selective brain cooling and the neuroprotective effects of only slightly lowering brain temperature. Therapeutic hypothermia for stroke has been shown to be feasible, but has yet to be definitively proven effective. There is clearly much work to be undertaken in this area.
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影响因子：
4.1
作者：
Ding, YC;Yao, B;Diaz, FG
通讯作者：
Diaz, FG
影响因子：
4.8
作者：
Ávila-Gómez P;Vieites-Prado A;Dopico-López A;Bashir S;Fernández-Susavila H;Gubern C;Pérez-Mato M;Correa-Paz C;Iglesias-Rey R;Sobrino T;Bustamante A;Wellmann S;Montaner J;Serena J;Castillo J;Hervella P;Campos F
通讯作者：
Campos F
影响因子：
48
作者：
Clifton, Guy L.;Valadka, Alex;Zygun, David;Coffey, Christopher S.;Drever, Pamala;Fourwinds, Sierra;Janis, L. Scott;Wilde, Elizabeth;Taylor, Pauline;Harshman, Kathy;Conley, Adam;Puccio, Ava;Levin, Harvey S.;McCauley, Stephen R.;Bucholz, Richard D.;Smith, Kenneth R.;Schmidt, John H.;Scott, James N.;Yonas, Howard;Okonkwo, David O.
通讯作者：
Okonkwo, David O.
影响因子：
3.5
作者：
Bakhsheshi, Mohammad Fazel;Keenliside, Lynn;Lee, Ting-Yim
通讯作者：
Lee, Ting-Yim
DOI：
10.1097/00004647-200207000-00009
发表时间：
2002-07-01
影响因子：
6.3
作者：
D'Cruz, BJ;Fertig, KC;Callaway, CW
通讯作者：
Callaway, CW