Therapeutic approaches for improving cognitive function in the aging brain.
Therapeutic approaches for improving cognitive function in the aging brain.
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DOI：
10.3389/fnins.2022.1060556
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发表时间：
2022
影响因子：
4.3
通讯作者：
Zhang, Yonggang
中科院分区：
文献类型：
--
作者：
Chen, Lingmin;Jiao, Jiao;Zhang, Yonggang
关键词：
全球人口的快速老龄化已经成为一个前所未有的挑战。衰老与认知障碍有关，包括痴呆和轻度认知障碍。成功的药物开发对于改善或维持老年人的认知是至关重要的。虽然已有4种药物被批准用于改善阿尔茨海默病的认知，但各种针对年龄相关认知障碍的潜在药物仍在开发中。此外，非药物干预，包括认知导向治疗、非侵入性脑刺激、体育锻炼和生活方式相关的干预，在过去十年中也被认为是认知增强剂。在本文中，我们回顾了旨在改善或维持老年人认知的药物和非药物干预的最新证据。
The rapid aging of populations around the world has become an unprecedented challenge. Aging is associated with cognitive impairment, including dementia and mild cognitive impairment. Successful drug development for improving or maintaining cognition in the elderly is critically important. Although 4 drugs for improving cognition in Alzheimer’s disease have been approved, a variety of potential drugs targeting age-related cognitive impairment are still in development. In addition, non-pharmacological interventions, including cognition-oriented treatments, non-invasive brain stimulation physical exercise, and lifestyle-related interventions, have also been suggested as cognitive enhancers in the last decade. In this paper, we reviewed the recent evidence of pharmacological and non-pharmacological interventions aimed at improving or maintaining cognition in the elderly.
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影响因子：
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Gerton, Brooke
DOI：
10.3233/jad-180263
发表时间：
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Journal of Alzheimer's disease : JAD
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10.1002/trc2.12179
发表时间：
2021
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Alzheimer's & dementia (New York, N. Y.)
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DOI：
10.1590/1516-4446-2017-0018
发表时间：
2019-01
期刊：
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
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48
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通讯作者：
Vellas, Bruno