Fibrosing cholestatic hepatitis: clinicopathologic spectrum, diagnosis and pathogenesis.
Fibrosing cholestatic hepatitis: clinicopathologic spectrum, diagnosis and pathogenesis.
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纤维化胆汁淤积性肝炎：临床病理学谱、诊断和发病机制。
DOI：
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发表时间：
2008
影响因子：
1.4
通讯作者：
Hanlin L. Wang
中科院分区：
文献类型：
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作者：
S. Xiao;Liang Lu;Hanlin L. Wang
纤维化胆汁淤积性肝炎（FCH）是一种进展迅速，有时致命的肝损伤形式。虽然最初在肝移植受者复发性B型肝炎中报道，但现在在免疫抑制下的慢性B或C型肝炎患者中频繁发现。肝脏的组织病理学特征包括明显的肝细胞损伤、严重的胆汁淤积、门静脉周围和细胞周围纤维化。其发病机制在很大程度上是未知的。本文综述的目的是描述FCH发生的临床条件，常见的组织病理学表现，某些基础疾病的独特特征，鉴别诊断中需要考虑的因素，以及我们目前对该病发病机制的认识。
Fibrosing cholestatic hepatitis (FCH) is a rapidly progressive, sometimes fatal form of liver injury. Though originally reported in liver transplant recipients with recurrent hepatitis B, it has now been recognized frequently in chronic hepatitis B or C patients who are under immunosuppression. The histopathologic hallmarks in the liver include marked hepatocytic injury, severe cholestasis, and periportal and pericellular fibrosis. The pathogenesis is largely unknown. The aim of this review is to describe the spectrum of clinical conditions in which FCH occurs, common histopathologic findings, features unique to certain underlying diseases, factors to be considered in differential diagnosis, and our current understanding of pathogenesis of this disease.
影响因子：
6.2
作者：
C. M. Toth;M. Pascual;R. Chung;F. Graeme-Cook;J. Dienstag;A. Bhan;A. Cosimi
通讯作者：
C. M. Toth;M. Pascual;R. Chung;F. Graeme-Cook;J. Dienstag;A. Bhan;A. Cosimi
影响因子：
6.4
作者：
Xiao, SY;Zhang, H;Tesh, RB
通讯作者：
Tesh, RB