Differential Regulation of Syngap1 Translation by FMRP Modulates eEF2 Mediated Response on NMDAR Activity
Differential Regulation of Syngap1 Translation by FMRP Modulates eEF2 Mediated Response on NMDAR Activity
复制标题
FMRP 对 Syngap1 翻译的差异调节调节 eEF2 介导的 NMDAR 活性反应
DOI：
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发表时间：
2019
影响因子：
4.8
通讯作者：
J. Clement
中科院分区：
文献类型：
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作者：
Abhik Paul;B. Nawalpuri;Devanshi Shah;Shruthi Sateesh;Ravi S Muddashetty;J. Clement
SYNGAP1, a Synaptic Ras-GTPase activating protein, regulates synapse maturation during a critical developmental window. Heterozygous mutation in SYNGAP1 (SYNGAP1-/+) has been shown to cause Intellectual Disability (ID) in children. Recent studies have provided evidence for altered neuronal protein synthesis in a mouse model of Syngap1-/+. However, the molecular mechanism behind the same is unclear. Here, we report the reduced expression of a known translation regulator, FMRP, during a specific developmental period in Syngap1-/+ mice. Our results demonstrate that FMRP interacts with and regulates the translation of Syngap1 mRNA. We further show reduced Fmr1 translation leads to decreased FMRP level during development in Syngap1-/+ which results in an increase in Syngap1 translation. These developmental changes are reflected in the altered response of eEF2 phosphorylation downstream of NMDA Receptor (NMDAR)-mediated signaling. In this study, we propose a cross-talk between FMRP and SYNGAP1 mediated signaling which can also explain the compensatory effect of impaired signaling observed in Syngap1-/+ mice.
影响因子：
16
作者：
Muddashetty RS;Nalavadi VC;Gross C;Yao X;Xing L;Laur O;Warren ST;Bassell GJ
通讯作者：
Bassell GJ
桶状皮质中 FMRP 的晶须刺激依赖性翻译需要激活 I 型代谢型谷氨酸受体。
DOI：
10.1016/s0169-328x(02)00657-5
发表时间：
2003
期刊：
Brain research. Molecular brain research
影响因子：
--
作者：
Todd,PeterK;Malter,JamesS;Mack,KennethJ
通讯作者：
Mack,KennethJ