Tissue-resident memory-like T cells in tumor immunity: Clinical implications.
Tissue-resident memory-like T cells in tumor immunity: Clinical implications.
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DOI：
10.1016/j.smim.2020.101415
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发表时间：
2020-06
影响因子：
7.8
通讯作者：
Dhodapkar KM
中科院分区：
文献类型：
--
作者：
Dhodapkar MV;Dhodapkar KM
组织驻留记忆（TRM）T细胞是在介导局部免疫中起重要作用的非循环淋巴细胞的独特群体。TRM样细胞现已被鉴定为几种人类肿瘤中肿瘤浸润淋巴细胞的组分，并与免疫治疗的结果和反应相关。TRM细胞还显示在鼠模型中介导抗肿瘤免疫。TRM细胞的生物学对临床癌症免疫治疗有几个意义。在这里，我们讨论了对TRM T细胞生物学的新见解，并讨论了它们对理解肿瘤中免疫微环境的异质性以及提高癌症疫苗，免疫检查点阻断和过继细胞疗法在临床上的疗效的影响。
Tissue-resident memory (TRM) T cells are distinct population of non-circulating lymphocytes that play an important role in mediating regional immunity. TRM- like cells have now been identified as a component of tumor-infiltrating lymphocytes in several human tumors and correlate with outcome and response to immunotherapy. TRM cells have also been shown to mediate anti-tumor immunity in murine models. Biology of TRM cells has several implications for clinical cancer immunotherapy. Here we discuss newer insights into the biology of TRM T cells and discuss their implications for understanding the heterogeneity of immune microenvironment in tumors as well as improving the efficacy of cancer vaccines, immune-checkpoint blockade and adoptive cellular therapies in the clinic.
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通讯作者：
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