Hageman factor, platelets and polyphosphates: early history and recent connection.
Hageman factor, platelets and polyphosphates: early history and recent connection.
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DOI：
10.1111/j.1538-7836.2010.03893.x
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发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
Wu Q
中科院分区：
文献类型：
--
作者：
Caen J;Wu Q
血小板活化和血液凝固对于止血是必不可少的，并且有助于各种其他生物过程，例如炎症、补体活化和组织修复。因子XII，最初称为Hageman因子，通过激活前激肽释放酶在激肽释放酶-激肽系统中起重要作用。在20世纪60年代，一种促进因子XII活化的血小板活性被鉴定出来，但其生物化学性质仍然未知。无机多磷酸盐（聚P）是由许多磷酸盐残基通过磷酸酐键连接而成的聚合物。这些聚合物存在于所有生物体中。在细菌中，聚P对生长和存活很重要。最近，聚P已被确定在人类血小板致密颗粒。研究表明，在血小板活化和分泌后，聚P激活因子XII，表明它最有可能是难以捉摸的血小板因子XII激活剂。Poly P还调节凝血和纤维蛋白溶解。本文就凝血因子XII的早期研究和血小板凝血因子XII活化活性的鉴定进行综述，并讨论聚P在凝血因子XII活化和凝血中的作用。
Platelet activation and blood coagulation are essential for hemostasis and contribute to a variety of other biological processes such as inflammation, complement activation and tissue repair. Factor XII, originally called Hageman factor, plays an important role in the kallikrein-kinin system by activating prekallikrein. In the 1960s, a platelet activity that promoted factor XII activation was identified but its biochemical nature remained unknown. Inorganic polyphosphates (poly P) are polymers that consist of many phosphate residues linked by phosphoanhydride bonds. These polymers exist in all living organisms. In bacteria, poly P is important for growth and survival. Recently, poly P has been identified in human platelet dense granules. Studied have shown that upon platelet activation and secretion, poly P activates factor XII, indicating that it is most likely the elusive platelet factor XII activator. Poly P also regulates coagulation and fibrinolysis. In this review, we focus on early studies of factor XII and the identification of platelet factor XII activation activity, and discuss recent findings of poly P in factor XII activation and coagulation.
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影响因子：
2.9
作者：
DAVIE, EW;FUJIKAWA, K;KISIEL, W
通讯作者：
KISIEL, W
影响因子：
4.8
作者：
KUMBLE, KD;KORNBERG, A
通讯作者：
KORNBERG, A
影响因子：
56.9
作者：
GAILANI, D;BROZE, GJ
通讯作者：
BROZE, GJ
影响因子：
56.9
作者：
DAVIE, EW;RATNOFF, OD
通讯作者：
RATNOFF, OD
DOI：
10.1016/0006-3002(56)90280-3
发表时间：
1956-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
KORNBERG, A;KORNBERG, SR;SIMMS, ES
通讯作者：
SIMMS, ES