Cancer and blood concentrations of the comutagen harmane in essential tremor.
Cancer and blood concentrations of the comutagen harmane in essential tremor.
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DOI：
10.1002/mds.22084
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发表时间：
2008-09-15
影响因子：
8.6
通讯作者：
Zheng, Wei
中科院分区：
文献类型：
--
作者：
Louis, Elan D.;Pellegrino, Kathryn M.;Factor-Litvak, Pam;Rios, Eileen;Jiang, Wendy;Henchcliffe, Claire;Zheng, Wei
Blood concentrations of harmane, a tremor-producing neurotoxin, are elevated in essential tremor (ET). Harmane is also a co-mutagen. To compare the prevalence of cancer in ET cases vs. controls, and determine whether blood harmane concentrations are elevated among ET cases with cancer. Case-control design. 66/267 (24.7%) ET cases vs. 55/331 (16.6%) controls had cancer (adjusted OR 1.52, 95% CI 1.01 – 2.30, p = 0.04). Among specific cancer types, colon cancer was more prevalent in ET cases than controls (2.6% vs. 0.6%, p = 0.04). Log blood harmane concentration was higher in ET cases vs. controls (p = 0.02) and in participants with vs. without cancer (p = 0.02). Log blood harmane concentration was highest in ET cases with cancer when compared with other groups (p = 0.009). These links between cancer and ET and between high blood harmane and cancer in ET deserve further study.
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影响因子：
9.9
作者：
Louis, ED;Zheng, W;Factor-Litvak, P
通讯作者：
Factor-Litvak, P
DOI：
10.1111/j.1532-5415.1968.tb02103.x
发表时间：
1968-01-01
影响因子：
6.3
作者：
LINN, BS;LINN, MW;GUREL, L
通讯作者：
GUREL, L
影响因子：
8.6
作者：
Martin, FC;Le, AT;Handforth, A
通讯作者：
Handforth, A
影响因子：
3
作者：
ROY, M;BOYER, L;BARBEAU, A
通讯作者：
BARBEAU, A
影响因子：
9.9
作者：
Louis, ED;Ford, B;Andrews, H
通讯作者：
Andrews, H