Modular organization of locomotor networks in people with severe spinal cord injury.
Modular organization of locomotor networks in people with severe spinal cord injury.
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DOI：
10.3389/fnins.2022.1041015
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发表时间：
2022
影响因子：
4.3
通讯作者：
Angeli, Claudia A.
中科院分区：
文献类型：
--
作者：
Sun, Soo Yeon;Giszter, Simon F.;Harkema, Susan J.;Angeli, Claudia A.
关键词：
以前的研究支持运动回路的模块化组织，有助于在运动过程中以空间和时间组织的方式激活肌肉。人的脊髓回路在脊髓损伤后可能会重组；然而，目前尚不清楚损伤后脊髓回路的重组是否会影响模块化组织。在这里，我们描述了不同慢性程度的完全性和不完全性脊髓损伤(SCI)受试者在任何明确的训练方案之前，在辅助踏步过程中表现出的运动肌肉活动的模块化协同组织。我们还调查了两名在脊髓硬膜外刺激训练后实现独立行走的受试者的协同特征是否发生了变化。为了捕捉步行过程中的协同结构，脊髓损伤患者被踩在体重支持的跑步机上，同时记录双侧腿部肌肉的肌电(EMG)。使用非负矩阵分解(NMF)和独立成分分析(ICA)对EMG进行分析，以确定协同模式。对不同临床特征的SCI受试者和非致残受试者(NDS)的协同作用模式进行了比较。NMF和ICA的结果表明，脊髓损伤受试者之间是相似的，但与NDS相比，标准方差捕捉的协同效应数量表现出更大的变异性，与NDS的相关性较弱。ICA比NMF产生更多的肌肉协同效应。此外，SCI受试者的临床特征和慢性化并不能预测在空间协同结构上的任何显著差异，尽管有任何神经可塑性改变。此外，在两个人中，培训后的协同效应并没有变得更接近ND的协同效应。这些发现表明，在SCI和NDS中表达的运动模块之间存在根本差异，并且在没有应用特定干预的情况下，SCI人群中运动模块的空间和时间协同稳定性具有显著水平。
Previous studies support modular organization of locomotor circuitry contributing to the activation of muscles in a spatially and temporally organized manner during locomotion. Human spinal circuitry may reorganize after spinal cord injury; however, it is unclear if reorganization of spinal circuitry post-injury affects the modular organization. Here we characterize the modular synergy organization of locomotor muscle activity expressed during assisted stepping in subjects with complete and incomplete spinal cord injury (SCI) of varying chronicity, before any explicit training regimen. We also investigated whether the synergy characteristics changed in two subjects who achieved independent walking after training with spinal cord epidural stimulation. To capture synergy structures during stepping, individuals with SCI were stepped on a body-weight supported treadmill with manual facilitation, while electromyography (EMGs) were recorded from bilateral leg muscles. EMGs were analyzed using non-negative matrix factorization (NMF) and independent component analysis (ICA) to identify synergy patterns. Synergy patterns from the SCI subjects were compared across different clinical characteristics and to non-disabled subjects (NDs). Results for both NMF and ICA indicated that the subjects with SCI were similar among themselves, but expressed a greater variability in the number of synergies for criterion variance capture compared to NDs, and weaker correlation to NDs. ICA yielded a greater number of muscle synergies than NMF. Further, the clinical characteristics of SCI subjects and chronicity did not predict any significant differences in the spatial synergy structures despite any neuroplastic changes. Further, post-training synergies did not become closer to ND synergies in two individuals. These findings suggest fundamental differences between motor modules expressed in SCIs and NDs, as well as a striking level of spatial and temporal synergy stability in motor modules in the SCI population, absent the application of specific interventions.
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DOI：
10.1523/jneurosci.6344-11.2012
发表时间：
2012-08-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Chvatal SA;Ting LH
通讯作者：
Ting LH
影响因子：
5.3
作者：
Godlove J;Gulati T;Dichter B;Chang E;Ganguly K
通讯作者：
Ganguly K
影响因子：
2.9
作者：
ENGLISH, AW;LENNARD, PR
通讯作者：
LENNARD, PR
影响因子：
2.5
作者：
de Leon, RD;Hodgson, JA;Edgerton, VR
通讯作者：
Edgerton, VR
影响因子：
2.9
作者：
BERGMANS, J;MILLER, S;REITSMA, DJ
通讯作者：
REITSMA, DJ