Enhanced anti-breast cancer efficacy of co-delivery liposomes of docetaxel and curcumin.
Enhanced anti-breast cancer efficacy of co-delivery liposomes of docetaxel and curcumin.
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多西他赛和姜黄素的共递送脂质体的抗胸腺癌疗效增强。
DOI：
10.3389/fphar.2022.969611
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发表时间：
2022
影响因子：
5.6
通讯作者：
Meng, Xiangyun
中科院分区：
文献类型：
--
作者：
Ye, Xi;Chen, Xin;He, Ruixi;Meng, Wangyang;Chen, Weidong;Wang, Fengling;Meng, Xiangyun
乳腺癌的成功治疗受到对正常细胞的毒性、肿瘤部位药物蓄积受损和多药耐药性的阻碍。为了解决乳腺癌化疗药物多药耐药（MDR）和化疗疗效低下的问题，我们设计了一种新型的多功能脂质体CUR-DTX-L，将姜黄素（CUR）和化疗药物多西他赛（DTX）联合应用于乳腺癌的治疗。CUR-DTX-L的平均粒径、多分散指数、zeta电位和包封率分别为208.53 ± 6.82 nm、0.055 ± 0.001、−23.1 ± 2.1 mV和98.32 ± 2.37%。体外释放实验和CCK-8测定结果表明，CUR-DTX-L具有较游离药物更好的缓释效果和抗肿瘤效果，MCF-7荷瘤小鼠证实了其抗肿瘤效果，CUR-DTX-L的抗肿瘤效果优于其他组，体内药代动力学研究表明，CUR-DTX-L的血药浓度-时间曲线、平均滞留时间、与游离药物相比，CUR-DTX-L的生物半衰期显著延长，有望成为一种协同治疗乳腺癌的药物载体。
The successful treatment of breast cancer is hampered by toxicity to normal cells, impaired drug accumulation at the tumor site, and multidrug resistance. We designed a novel multifunctional liposome, CUR-DTX-L, to co-deliver curcumin (CUR) and the chemotherapeutic drug docetaxel (DTX) for the treatment of breast cancer in order to address multidrug resistance (MDR) and the low efficacy of chemotherapy. The mean particle size, polydispersity index, zeta potential, and encapsulation efficiency of CUR-DTX-L were 208.53 ± 6.82 nm, 0.055 ± 0.001, −23.1 ± 2.1 mV, and 98.32 ± 2.37%, respectively. An in vitro release study and CCK-8 assays showed that CUR-DTX-L has better sustained release effects and antitumor efficacy than free drugs, the antitumor efficacy was verified by MCF-7 tumor-bearing mice, the CUR-DTX-L showed better antitumor efficacy than other groups, and the in vivo pharmacokinetic study indicated that the plasma concentration–time curve, mean residence time, and biological half-life time of CUR-DTX-L were significantly increased compared with free drugs, suggesting that it is a promising drug delivery system for the synergistic treatment of breast cancer.
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影响因子：
5.8
作者：
Abouzeid, Abraham H.;Patel, Niravkumar R.;Torchilin, Vladimir P.
通讯作者：
Torchilin, Vladimir P.
影响因子：
2
作者：
Berrios-Caro, Ernesto;Gifford, Danna R.;Galla, Tobias
通讯作者：
Galla, Tobias
鼠李糖脂修饰姜黄素脂质体稳定性、载量及缓释性能的提高
影响因子：
5.8
作者：
Cheng, Ce;Wu, Zhihua;Liu, Wei
通讯作者：
Liu, Wei
影响因子：
4.5
作者：
Cheng Ji;Wen Na;Zhu Jia-Bi
通讯作者：
Zhu Jia-Bi
影响因子：
3.4
作者：
Du, S.;Deng, Y.
通讯作者：
Deng, Y.