Impact of Source and Manufacturing of Collagen Matrices on Fibroblast Cell Growth and Platelet Aggregation.
Impact of Source and Manufacturing of Collagen Matrices on Fibroblast Cell Growth and Platelet Aggregation.
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DOI：
10.3390/ma10091086
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发表时间：
2017-09-15
期刊：
影响因子：
--
通讯作者：
Charwat V
中科院分区：
文献类型：
--
作者：
Böhm S;Strauß C;Stoiber S;Kasper C;Charwat V
胶原蛋白是细胞外基质的主要成分。它经常用于医疗应用，以支持组织再生、止血或伤口愈合。由于胶原蛋白的来源不同，现有产品的特性和性能可能会有很大差异。在这项体外研究中，对来自牛、马和猪来源的七种不同的胶原基质进行了比较。以成纤维细胞支架功能和血小板聚集功能为性能指标。我们发现在不同的胶原材料上，血小板聚集和成纤维细胞的生长有很大的差异。观察到的差异不能仅仅归因于物种的差异，而是高度依赖于制造过程中的差异。
Collagen is a main component of the extracellular matrix. It is often used in medical applications to support tissue regeneration, hemostasis, or wound healing. Due to different sources of collagen, the properties and performance of available products can vary significantly. In this in vitro study, a comparison of seven different collagen matrices derived from bovine, equine, and porcine sources was performed. As performance indicators, the scaffold function for fibroblasts and platelet aggregation were used. We found strong variation in platelet aggregation and fibroblast growth on the different collagen materials. The observed variations could not be attributed to species differences alone, but were highly dependent on differences in the manufacturing process.
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