Engineered in vitro tumor models for cell-based immunotherapy.
Engineered in vitro tumor models for cell-based immunotherapy.
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设计用于基于细胞的免疫疗法的体外肿瘤模型。
DOI：
10.1016/j.actbio.2021.03.076
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发表时间：
2021-09-15
影响因子：
9.7
通讯作者：
Shen K
中科院分区：
文献类型：
--
作者：
Ando Y;Mariano C;Shen K
Tumor immunotherapy is rapidly evolving as one of the major pillars of cancer treatment. Cell-based immunotherapies, which utilize patient’s own immune cells to eliminate cancer cells, have shown great promise in treating a range of malignancies, especially those of hematopoietic origins. However, their performance on a broader spectrum of solid tumor types still fall short of expectations in the clinical stage despite of the promising preclinical assessments. In this review, we briefly introduce cell-based immunotherapies and the inhibitory mechanisms in tumor microenvironments that may have contributed to this discrepancy. Specifically, a major obstacle to the clinical translation of cell-based immunotherapies is in the lack of preclinical models that can accurately assess the efficacies and mechanisms of these therapies in a (patho-)physiologically relevant manner. Lately, tissue engineering and organ-on-a-chip tools and microphysiological models have allowed for more faithful recapitulation of the tumor microenvironments, by incorporating crucial tumor tissue features such as cellular phenotypes, tissue architecture, extracellular matrix, physical parameters, and their dynamic interactions. This review summarizes the existing engineered tumor models with a focus on tumor immunology and cell-based immunotherapy. We also discuss some key considerations for the future development of engineered tumor models for immunotherapeutics.
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影响因子：
4.6
作者：
Agliari E;Biselli E;De Ninno A;Schiavoni G;Gabriele L;Gerardino A;Mattei F;Barra A;Businaro L
通讯作者：
Businaro L
影响因子：
11.2
作者：
Barsoum, Ivraym B.;Smallwood, Chelsea A.;Graham, Charles H.
通讯作者：
Graham, Charles H.
影响因子：
8.8
作者：
Aras S;Zaidi MR
通讯作者：
Zaidi MR
影响因子：
82.9
作者：
Binnewies M;Roberts EW;Kersten K;Chan V;Fearon DF;Merad M;Coussens LM;Gabrilovich DI;Ostrand-Rosenberg S;Hedrick CC;Vonderheide RH;Pittet MJ;Jain RK;Zou W;Howcroft TK;Woodhouse EC;Weinberg RA;Krummel MF
通讯作者：
Krummel MF
影响因子：
6.1
作者：
Aref AR;Campisi M;Ivanova E;Portell A;Larios D;Piel BP;Mathur N;Zhou C;Coakley RV;Bartels A;Bowden M;Herbert Z;Hill S;Gilhooley S;Carter J;Cañadas I;Thai TC;Kitajima S;Chiono V;Paweletz CP;Barbie DA;Kamm RD;Jenkins RW
通讯作者：
Jenkins RW