The Lewis A phenotype is a restriction factor for Rotateq and Rotarix vaccine-take in Nicaraguan children.
The Lewis A phenotype is a restriction factor for Rotateq and Rotarix vaccine-take in Nicaraguan children.
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刘易斯表型是尼加拉瓜儿童RotateQ和Rotarix疫苗接种的限制因素。
DOI：
10.1038/s41598-018-19718-y
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发表时间：
2018-01-24
影响因子：
4.6
通讯作者：
Svensson L
中科院分区：
文献类型：
--
作者：
Bucardo F;Nordgren J;Reyes Y;Gonzalez F;Sharma S;Svensson L
组织血型抗原（HBGAs）和刘易斯和分泌抗原与轮状病毒感染的易感性以基因型依赖的方式。哥伦比亚儿童前瞻性入组接种RotaTeq RV 5（n = 68）或Rotarix RV 1（n = 168）的两个队列。刘易斯和分泌抗原通过唾液表型和基因分型确定。血清转换定义为首次接种疫苗后1个月血浆伊加抗体滴度增加4倍。无论接种哪种疫苗，与刘易斯B表型的26%（45/175）和刘易斯阴性个体的32%（15/47）相比，在接种第一剂疫苗后，刘易斯A表型的儿童（0/14）血清转化显著较少（P < 0.01）。此外，接种RV 1疫苗后，分泌型阳性ABO血型B儿童的血清转化率（5%）显著低于分泌型阳性ABO血型A（26%）和O（27%）儿童（P < 0.05）。其他因素如接种前滴度、性别、母乳喂养和钙卫蛋白水平不影响接种。HBGA表达的差异似乎是疫苗接种差异的一个促成因素，因此，在不同种族人群中的疫苗效力。
Histo-blood group antigens (HBGAs) and the Lewis and secretor antigens are associated with susceptibility to rotavirus infection in a genotype-dependent manner. Nicaraguan children were prospectively enrolled in two cohorts vaccinated with either RotaTeq RV5 (n = 68) or Rotarix RV1 (n = 168). Lewis and secretor antigens were determined by saliva phenotyping and genotyping. Seroconversion was defined as a 4-fold increase in plasma IgA antibody titer 1 month after administration of the first dose of the vaccine. Regardless of the vaccine administered, significantly fewer of the children with Lewis A phenotype (0/14) seroconverted after receiving the first vaccine dose compared to 26% (45/175) of those with the Lewis B phenotype and 32% (15/47) of the Lewis negative individuals (P < 0.01). Furthermore, following administration of the RV1 vaccine, secretor-positive ABO blood group B children seroconverted to a significantly lesser extent (5%) compared to secretor-positive children with ABO blood groups A (26%) and O (27%) (P < 0.05). Other factors such as pre-vaccination titers, sex, breastfeeding, and calprotectin levels did not influence vaccine-take. Differences in HBGA expression appear to be a contributing factor in the discrepancy in vaccine-take and thus, in vaccine efficacy in different ethnic populations.
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DOI：
10.5114/pg.2017.70469
发表时间：
2017-01-01
影响因子：
1.3
作者：
Elnady, Hala Gouda;Samie, Ola M. Abdel;El-Taweel, Ahmed N.
通讯作者：
El-Taweel, Ahmed N.
影响因子：
168.9
作者：
Bernstein, DI;Sack, DA;Ward, RL
通讯作者：
Ward, RL
影响因子：
168.9
作者：
Armah, George E.;Sow, Samba O.;Neuzil, Kathleen M.
通讯作者：
Neuzil, Kathleen M.
影响因子：
6.4
作者：
Kazi, Abdul Momin;Cortese, Margaret M.;Ali, Asad
通讯作者：
Ali, Asad
影响因子：
3.7
作者：
de Oliveira Corvelo, Tereza Cristina;Pompeu de Loiola, Rosane do Socorro;de Brito, Danielle Calado
通讯作者：
de Brito, Danielle Calado