Connections between 3'-end processing and DNA damage response.
Connections between 3'-end processing and DNA damage response.
复制标题
3'-End处理与DNA损伤响应之间的连接。
DOI：
10.1002/wrna.20
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发表时间：
2010-07
影响因子：
7.3
通讯作者：
Kleiman, Frida E.
中科院分区：
文献类型：
--
作者：
Cevher, Murat A.;Kleiman, Frida E.
细胞DNA损伤反应（DDR）涉及许多核蛋白的功能和结构特性的变化，导致基因表达和DNA修复的协调控制。这种反应包括DNA修复、转录和RNA加工机制的功能性相互作用。DNA损伤后，多聚腺苷酸化转录物的细胞水平短暂降低，正常恢复依赖于转录偶联修复（TCR）。此外，DNA损伤具有基因特异性作用，在损伤后的不同时间调节DDR本身所涉及的因子的mRNA水平。3′-末端加工机制在mRNA稳定性的调节中起重要作用，参与了对DNA损伤的一般和基因特异性反应。DDR中3′-末端加工的作用支持了这样的观点，即不同mRNA的稳态水平在DNA损伤条件下发生变化，这不仅是其生物合成的调节，也是其周转的结果。本文综述了3′-末端加工和DDR之间的机制联系，并讨论了这一重要的mRNA成熟步骤在DNA损伤处理后细胞恢复中的意义。关于这一相对未经探索的领域的报告越来越多，说明了这些职能联系的相关性。
The cellular DNA damage response (DDR) involves changes in the functional and structural properties of a number of nuclear proteins, resulting in a coordinated control of gene expression and DNA repair. This response includes functional interactions of the DNA repair, transcription, and RNA processing machineries. Following DNA damage, cellular levels of polyadenylated transcripts are transiently decreased and normal recovery depends on transcription-coupled repair (TCR). In addition, DNA damage has gene-specific effects regulating the mRNA levels of factors involved in the DDR itself at different times after the damage. The 3′-end processing machinery, which is important in the regulation of mRNA stability, is involved in these general and gene-specific responses to DNA damage. The role of 3′-end processing in DDR supports the idea that the steady-state levels of different mRNAs change upon DNA-damaging conditions as a result of regulation of not only their biosynthesis but also their turnover. Here, we review the mechanistic connections between 3′-end processing and DDR, and discuss the implications of deregulation of this important step of mRNA maturation in the cellular recovery after DNA-damaging treatment. The relevance of these functional connections is illustrated by the increasing number of reports on this relatively unexplored field.
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