Parkinson's disease as a disconnection syndrome.
Parkinson's disease as a disconnection syndrome.
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DOI：
10.1007/s11065-010-9128-8
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发表时间：
2010-06
影响因子：
5.8
通讯作者：
Cronin-Golomb, Alice
中科院分区：
文献类型：
--
作者：
Cronin-Golomb, Alice
帕金森病（PD）是一种主要的神经退行性疾病，通常被认为是中脑和基底神经节功能障碍。将帕金森病视为一种脱节综合症可能有助于理解该疾病的认知、知觉和其他神经心理学领域。 PD通常是单侧发病，提供半球内解离和左右半球通常相对强度不平衡的证据。因此，为了理解帕金森病的神经心理学，重要的是要将我们对半球偏侧化效应和从脑干到高阶关联皮层的半球内回路的理解应用于这种疾病。本综述的重点是皮层下和皮层结构之间与 PD 相关的脱节与认知、知觉、情绪以及相关的脑干领域（如睡眠和情绪障碍）的相关性。除了提供有关疾病特征的信息外，将帕金森病视为一种断开综合症可以让我们更全面地了解正常的大脑行为关系。
Parkinson’s disease (PD) is a major neuro-degenerative disorder that is usually considered in terms of midbrain and basal ganglia dysfunction. Regarding PD instead as a disconnection syndrome may prove beneficial to understanding aspects of cognition, perception, and other neuropsychological domains in the disease. PD is usually of unilateral onset, providing evidence of intrahemispheric dissociations and an imbalance in the usual relative strengths of the right and left hemispheres. Hence, in order to appreciate the neuropsychology of PD, it is important to apply to this disease our understanding of hemispheric lateralization effects and within-hemisphere circuitry from brainstem to higher-order association cortex. The focus of this review is on the relevance of PD-related disconnections among subcortical and cortical structures to cognition, perception, emotion, and associated brainstem-based domains such as sleep and mood disturbance. Besides providing information on disease characteristics, regarding PD as a disconnection syndrome allows us to more completely understand normal brain-behavior relations in general.
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