Sidestream Smoke Affects Dendritic Complexity and Astrocytes After Model Mild Closed Head Traumatic Brain Injury.
Sidestream Smoke Affects Dendritic Complexity and Astrocytes After Model Mild Closed Head Traumatic Brain Injury.
复制标题
侧流烟雾影响轻度闭合性颅脑损伤模型后树突复杂性和星形胶质细胞。
DOI：
10.1007/s10571-020-01036-5
复制
发表时间：
2022-07
影响因子：
4
通讯作者：
Citron BA
中科院分区：
文献类型：
--
作者：
Ratliff WA;Saykally JN;Keeley KL;Driscoll DC;Murray KE;Okuka M;Mervis RF;Delic V;Citron BA
轻度脑外伤可能会产生长期后果，干扰患者的生活，并给我们的医疗保健系统带来负担。氧化应激已被确定为TBI后神经变性进展的一个促成因素。对许多退伍军人来说，氧化应激的一个主要来源是吸烟和二手烟，这已被证明对TBI恢复有影响。为了研究二手烟在TBI恢复过程中的潜在影响，我们使用了闭合性头部损伤的小鼠模型，然后反复暴露于香烟烟雾并使用神经保护性抗氧化剂进行治疗。我们发现无论是轻度损伤还是烟雾暴露都没有产生用氨基铜银染色可检测到的轴突损伤。然而，在轻度TBI加烟雾暴露后，树突状乔木的复杂性显着降低。在海马，有星形胶质细胞的反应，包括Cyp2e1上调，损伤和烟草烟雾损伤后。这项研究为生活方式改变的重要性提供了有用的背景，例如在TBI恢复期间减少或消除吸烟。
Mild traumatic brain injuries can have long-term consequences that interfere with the life of the patient and impose a burden on our health care system. Oxidative stress has been identified as a contributing factor for the progression of neurodegeneration following TBI. A major source of oxidative stress for many veterans is cigarette smoking and second-hand smoke, which has been shown to have an effect on TBI recovery. To examine the potential influences of second-hand smoke during recovery from TBI, we utilized a mouse model of closed head injury, followed by repeated exposure to cigarette smoke and treatment with a neuroprotective antioxidant. We found that neither the mild injuries nor the smoke exposure produced axonal damage detectable with amino cupric silver staining. However, complexity in the dendritic arbors was significantly reduced after mild TBI plus smoke exposure. In the hippocampus, there were astrocytic responses, including Cyp2e1 upregulation, after the injury and tobacco smoke insult. This study provides useful context for the importance of lifestyle changes, such as reducing or eliminating cigarette smoking, during recovery from TBI.
登录
查看更多内容
影响因子：
2.9
作者：
Ratliff WA;Delic V;Pick CG;Citron BA
通讯作者：
Citron BA
影响因子：
5.3
作者：
Burda JE;Bernstein AM;Sofroniew MV
通讯作者：
Sofroniew MV
DOI：
10.1124/jpet.109.157776
发表时间：
2010-02-01
影响因子：
3.5
作者：
Paulson, Jennifer R.;Yang, Tianzhi;Abbruscato, Thomas J.
通讯作者：
Abbruscato, Thomas J.
影响因子：
3.3
作者：
Morrison HW;Filosa JA
通讯作者：
Filosa JA
影响因子：
2.3
作者：
Huf, Fernanda;Bandiera, Solange;Fernandes, Marilda da Cruz
通讯作者：
Fernandes, Marilda da Cruz