The role of histone ubiquitination during spermatogenesis.
The role of histone ubiquitination during spermatogenesis.
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组蛋白泛素化在精子发生过程中的作用
DOI：
10.1155/2014/870695
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发表时间：
2014
影响因子：
--
通讯作者：
Xu W
中科院分区：
文献类型：
--
作者：
Sheng K;Liang X;Huang S;Xu W
蛋白质泛素-蛋白酶体系统是真核细胞中蛋白质降解的主要机制。在精子发生过程中，组蛋白被鱼精蛋白取代对正常精子的形成至关重要，这与睾丸中表达的泛素化酶有关。近年来，组蛋白泛素连接酶在精子发生的多个方面发挥着重要作用，如减数分裂性染色体失活（MSCI）、DNA损伤反应和精子发生。在这篇综述中，我们强调了最近发现的几个组蛋白泛素连接酶和详细的机制，这些酶是如何参与这些过程中，通过敲除小鼠模型。以Huwe 1、UBR 2和RNF 8为例，着重介绍了这三种酶的不同功能，以及它们在精原细胞分化、减数分裂和精子发生等各个阶段的广泛参与;因此，组蛋白泛素连接酶代表了一类酶，其通过靶向组蛋白进行泛素化而在精子发生中发挥重要作用，因此涉及转录调节，表观遗传修饰，以及其他正常配子形成所必需的过程。
Protein ubiquitin-proteasome (ubiquitin-proteasome) system is the major mechanism responsible for protein degradation in eukaryotic cell. During spermatogenesis, the replacement of histone by protamine is vital for normal sperm formation, which is involved in ubiquitination enzymes expressed in testis. Recently, histone ubiquitin ligases have been shown to play critical roles in several aspects of spermatogenesis, such as meiotic sex chromosome inactivation (MSCI), DNA damage response, and spermiogenesis. In this review, we highlight recent progress in the discovery of several histone ubiquitin ligases and elaborate mechanisms of how these enzymes are involved in these processes through knockout mouse model. Using Huwe1, UBR2, and RNF8 as examples, we emphasized the diverse functions for each enzyme and the broad involvement of these enzymes in every stage, from spermatogonia differentiation and meiotic division to spermiogenesis; thus histone ubiquitin ligases represent a class of enzymes, which play important roles in spermatogenesis through targeting histone for ubiquitination and therefore are involved in transcription regulation, epigenetic modification, and other processes essential for normal gametes formation.
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影响因子：
16.8
作者：
Choi, Woo Suk;Jeong, Byung-Cheon;Song, Hyun Kyu
通讯作者：
Song, Hyun Kyu
对精子发生过程中泛素蛋白酶体途径（UPP）机制的新见解。
影响因子：
2.8
作者：
Hou, Cong-Cong;Yang, Wan-Xi
通讯作者：
Yang, Wan-Xi
影响因子：
16.8
作者：
Brykczynska, Urszula;Hisano, Mizue;Peters, Antoine H. F. M.
通讯作者：
Peters, Antoine H. F. M.
DOI：
10.1073/pnas.0910267107
发表时间：
2010-02-02
影响因子：
11.1
作者：
An, Jee Young;Kim, Eun-A.;Kwon, Yong Tae
通讯作者：
Kwon, Yong Tae
影响因子：
3.7
作者：
An JY;Kim E;Zakrzewska A;Yoo YD;Jang JM;Han DH;Lee MJ;Seo JW;Lee YJ;Kim TY;de Rooij DG;Kim BY;Kwon YT
通讯作者：
Kwon YT