Alcohol amplifies cingulate cortex signaling and facilitates immobilization-induced hyperalgesia in female rats.
Alcohol amplifies cingulate cortex signaling and facilitates immobilization-induced hyperalgesia in female rats.
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酒精放大了雌性大鼠的扣带皮质信号并促进了固定化诱导的痛觉过敏。
DOI：
10.1016/j.neulet.2021.136119
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发表时间：
2021-09-14
影响因子：
2.5
通讯作者：
Edwards S
中科院分区：
文献类型：
--
作者：
Cucinello-Ragland JA;Mitchell-Cleveland R;Bradley Trimble W;Urbina AP;Yeh AY;Edwards KN;Molina PE;Simon Peter L;Edwards S
复杂区域疼痛综合征 (CRPS) 是一种肌肉骨骼疼痛病症，通常在肢体受伤和/或制动后出现。尽管 CRPS 的确切机制尚不清楚，但该综合征与中枢和自主神经系统失调以及周围痛觉过敏症状有关。这些症状也出现在酒精性神经病中，表明这两种情况可能在病理生理学上加重。有趣的是，出生时被指定为女性 (AFAB) 的人似乎对 CRPS 和酒精性神经病更敏感。为了更好地了解这些病症背后的生物行为机制，我们研究了雌性大鼠 CRPS 和酒精性神经病联合模型。动物被配对饲喂 Lieber-DeCarli 酒精液体饮食或对照饮食十周。 CRPS 通过单侧后肢石膏固定 7 天进行建模，允许另一肢作为痛觉过敏措施的受试者内对照。为了研究循环卵巢激素对疼痛相关行为的作用，一半的动物接受了卵巢切除术（OVX）。使用 von Frey 程序记录机械缩爪阈值，我们发现石膏固定和长期饮酒分别和相加地产生了在石膏去除后 3 天观察到的机械痛觉过敏。然后，我们检查了所有组双侧运动皮层和扣带皮层中 AMPA GluR1 和 NMDA NR1 谷氨酸通道亚基、细胞外信号调节激酶 (ERK) 和 cAMP 反应元件结合蛋白 (CREB) 的神经适应。与疼痛相关行为的增加一致，长期饮酒会增加扣带皮层中 GluR1、NR1、ERK 和 CREB 的磷酸化。 OVX 没有改变任何观察到的效果。我们的研究结果表明 CRPS 和酒精性神经病症状之间存在递增关系，并为这些疾病指出了新的治疗靶点。
Complex Regional Pain Syndrome (CRPS) is a musculoskeletal pain condition that often develops after limb injury and/or immobilization. Although the exact mechanisms underlying CRPS are unknown, the syndrome is associated with central and autonomic nervous system dysregulation and peripheral hyperalgesia symptoms. These symptoms also manifest in alcoholic neuropathy, suggesting that the two conditions may be pathophysiologically accretive. Interestingly, people assigned female at birth (AFAB) appear to be more sensitive to both CRPS and alcoholic neuropathy. To better understand the biobehavioral mechanisms underlying these conditions, we investigated a model of combined CRPS and alcoholic neuropathy in female rats. Animals were pair-fed either a Lieber-DeCarli alcohol liquid diet or a control diet for ten weeks. CRPS was modeled via unilateral hind limb cast immobilization for seven days, allowing for the other limb to serve as a within-subject control for hyperalgesia measures. To investigate the role of circulating ovarian hormones on pain-related behaviors, half of the animals underwent ovariectomy (OVX). Using the von Frey procedure to record mechanical paw withdrawal thresholds, we found that cast immobilization and chronic alcohol drinking separately and additively produced mechanical hyperalgesia observed 3 days after cast removal. We then examined neuroadaptations in AMPA GluR1 and NMDA NR1 glutamate channel subunits, extracellular signal-regulated kinase (ERK), and cAMP response element-binding protein (CREB) in bilateral motor and cingulate cortex across all groups. Consistent with increased pain-related behavior, chronic alcohol drinking increased GluR1, NR1, ERK, and CREB phosphorylation in the cingulate cortex. OVX did not alter any of the observed effects. Our results suggest accretive relationships between CRPS and alcoholic neuropathy symptoms and point to novel therapeutic targets for these conditions.
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影响因子：
1.5
作者：
Bass, Christopher;Yates, Gregory
通讯作者：
Yates, Gregory
DOI：
10.1111/acer.13252
发表时间：
2016-12
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Bergeson SE;Blanton H;Martinez JM;Curtis DC;Sherfey C;Seegmiller B;Marquardt PC;Groot JA;Allison CL;Bezboruah C;Guindon J
通讯作者：
Guindon J
影响因子：
14.5
作者：
Critchley, HD;Mathias, CJ;Dolan, RJ
通讯作者：
Dolan, RJ
影响因子：
2.6
作者：
de Mos, M.;Huygen, F. J. P. M.;Sturkenboom, M. C. J. M.
通讯作者：
Sturkenboom, M. C. J. M.
1型复杂性区域疼痛综合征（CRPS1）发病过程中的人口统计学和医学参数： 对 596 名骨折患者的前瞻性研究
影响因子：
7.4
作者：
Beerthuizen, Annemerle;Stronks, Dirk L.;Huygen, Frank J. P. M.
通讯作者：
Huygen, Frank J. P. M.