Tissue tectonics and the multi-scale regulation of developmental timing.
Tissue tectonics and the multi-scale regulation of developmental timing.
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DOI：
10.1098/rsfs.2020.0057
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发表时间：
2021-06-06
期刊：
影响因子：
4.4
通讯作者：
Steventon B
中科院分区：
文献类型：
--
作者：
Busby L;Steventon B
发育包括发生在多个长度尺度上的过程，包括基因调控相互作用、细胞运动和重组、细胞信号传导和生长。至关重要的是，所有这些不同过程中的事件的时间是协调的，以产生良好的组织和器官。然而，内在细胞状态变化的时间如何与多组织和整个生物体水平上发生的事件协调尚不清楚。在这里，我们认为，一个重要的机制，占跨层次的组织整合的时间是由组织构造，即形态发生事件驱动组织形状的变化如何导致信号和响应组织的相对位移和协调发展的时间跨越尺度。在这样做时，组织构造提供了一种机制，通过该机制，细胞内在的细胞特化事件可以通过暂时暴露于细胞外信号来调节。这种暴露反过来又受到胚胎的高级特性的调节，例如它们的物理特性、生长速率和动态细胞行为的组合，从而影响组织形态发生。组织构造学创造了一种从生物组织的较高层次到较低层次的向下信息流，提供了发育中向下因果关系的一个实例。
Development encompasses processes that occur at multiple length scales, including gene-regulatory interactions, cell movements and reorganization, cell signalling and growth. It is essential that the timing of events in all of these different processes is coordinated to generate well-patterned tissues and organs. However, how the timing of intrinsic cell state changes is coordinated with events occurring at the multi-tissue and whole-organism level is unknown. Here, we argue that an important mechanism that accounts for the integration of timing across levels of organization is provided by tissue tectonics, i.e. how morphogenetic events driving tissue shape changes result in the relative displacement of signalling and responding tissues and coordinate developmental timing across scales. In doing so, tissue tectonics provides a mechanism by which the cell specification events intrinsic to cells can be modulated by the temporal exposure to extracellular signals. This exposure is in turn regulated by higher-order properties of the embryo, such as their physical properties, rates of growth and the combination of dynamic cell behaviours, impacting tissue morphogenesis. Tissue tectonics creates a downward flow of information from higher to lower levels of biological organization, providing an instance of downward causation in development.
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DOI：
10.1242/dev.164368
发表时间：
2018-06-26
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Ebisuya M;Briscoe J
通讯作者：
Briscoe J
影响因子：
11.8
作者：
Grosskortenhaus, R;Pearson, BJ;Doe, CQ
通讯作者：
Doe, CQ
影响因子：
56.9
作者：
Hirata, H;Yoshiura, S;Kageyama, R
通讯作者：
Kageyama, R
影响因子：
9.2
作者：
Gao, FB;Durand, B;Raff, M
通讯作者：
Raff, M
影响因子：
4.6
作者：
Britton, George;Heemskerk, Idse;Warmflash, Aryeh
通讯作者：
Warmflash, Aryeh