Correlation of viral loads with HCV genotypes: higher levels of virus were revealed among blood donors infected with 6a strains.
Correlation of viral loads with HCV genotypes: higher levels of virus were revealed among blood donors infected with 6a strains.
复制标题
病毒载量与HCV基因型的相关性：感染6A菌株的献血者中较高的病毒。
DOI：
10.1371/journal.pone.0052467
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Nelson KE
中科院分区：
文献类型：
--
作者：
Rong X;Lu L;Wang J;Xiong H;Huang J;Chen J;Huang K;Xu R;Wang M;Zhang X;Guo T;Liu Y;Gao G;Fu Y;Nelson KE
HCV基因型和病毒载量都是α-干扰素联合利巴韦林治疗患者疗效的预测因子;然而，这种相关性仅在基因型1、2和3中进行了研究，而在基因型6中尚未进行研究。招募了299名HCV病毒血症的自愿献血者。他们的平均年龄为31.8岁;男性/女性比例为3.82（225/59）。采用COBAS AmpliPrep/COBAS TaqMan试验（CAP/CTM）测定HCV病毒载量，同时通过NS 5 B部分区域直接测序确定HCV基因型。48.9%、8.7%、12.3%和30.1%的献血者检测出HCV基因型1、2、3和6，基因型1和6的平均病毒载量水平明显高于基因型2和3（P<0.001）。总体上，男性献血员的病毒载量高于女性（P = 0.006）。 此外，献血员的性别和HCV基因型与测量的病毒载量独立相关。HCV基因型1和6的病毒载量显著高于基因型2和3。
Both HCV genotypes and viral loads are predictors of therapeutic outcomes among patients treated with α-interferon plus ribavirin; however, such correlation has only been studied for genotypes 1, 2, and 3 but not for genotype 6. 299 voluntary blood donors were recruited who were HCV viremic. Their mean age was 31.8; the male/female ratio was 3.82 (225/59). The viral loads of HCV were measured using the COBAS AmpliPrep/COBAS TaqMan test (CAP/CTM) while HCV genotypes were determined by direct sequencing the partial NS5B region. HCV genotypes 1, 2, 3, and 6 were determined in 48.9%, 8.7%, 12.3%, and 30.1% of the donors, respectively, and the levels of mean viral loads in genotype 1 and 6 significantly higher than that of 2 and 3 (P<0.001). As a whole, the viral loads in male donors were higher than in female (P = 0.006). Moreover, the donors' gender and HCV genotypes are independently correlated with the measured viral loads. HCV genotype 1 and 6 had significantly higher viral loads than genotype 2 and 3.
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