Cerebral fractional anisotropy score in trauma patients: a new indicator of white matter injury after trauma.
Cerebral fractional anisotropy score in trauma patients: a new indicator of white matter injury after trauma.
复制标题
创伤患者脑各向异性分数：创伤后白质损伤的新指标。
DOI：
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
R. Novelline
中科院分区：
文献类型：
--
作者：
T. Ptak;R. Sheridan;J. Rhea;A. Gervasini;Jong H Yun;Marjorie A Curran;Pierre Borszuk;L. Petrovick;R. Novelline
目的
先前评估定量脑白色物质弥散各向异性指数的研究显示创伤后患者的改变。到目前为止，还没有临床上适用的量表来衡量和测试这些发现的相关性。我们提出脑外伤各向异性分数（C-FAST）作为白色物质损伤的指标，并将C-FAST与几个预测因子和结果变量相关联。
材料和方法
从创伤外科服务中随机选择了15名患者。从急诊科随机选择30名对照患者。所有患者均接受MRI评价，包括弥散加权序列。从每例受试者的记录中提取的数据包括格拉斯哥昏迷量表、修订的创伤评分、简化损伤量表、初始头部CT结果、患者分布、住院时间和重症监护室住院时间。在12个白色物质区域中的每一个中的分数各向异性图中进行感兴趣区域测量。对原始各向异性分数数据进行单变量统计和双尾t检验。然后使用来自单变量统计的阈值对数据进行二分。根据二分数据设计C-FAST评分。对C-FAST、结果和预测数据进行Logistic回归分析。
结果
注意到C-FAST与死亡、住院时间超过10天和重症监护室住院时间超过5天之间存在良好的相关性。在调整年龄和性别后，出院到康复机构的相关性良好。格拉斯哥昏迷评分、修订创伤评分和简化损伤评分作为临界C-FAST的预测因子显示出良好的相关性。
结论
C-FAST是一个很有前途的指数，来自MRI弥散分数各向异性测量，显示成功的结果和预测变量的相关性。需要更大规模的调查来验证相关性的有效性和稳定性。
OBJECTIVE
Previous studies evaluating quantitative cerebral white matter diffusion anisotropy indexes have shown alteration in patients after trauma. To date, no clinically applicable scale exists by which to gauge and test the relevance of these findings. We propose the cerebral fractional anisotropy score in trauma (C-FAST) as an index of white matter injury, and we correlate C-FAST with several predictor and outcome variables.
MATERIALS AND METHODS
Fifteen patients were randomly selected from the trauma surgery service. Thirty control patients were randomly selected from the emergency department. All patients were subjected to MRI evaluation, including a diffusion-weighted sequence. Data extracted from the record of each subject included Glasgow Coma Scale, revised trauma score, Abbreviated Injury Scale, initial head CT results, patient disposition, length of hospital stay, and length of stay in intensive care unit. Region of interest measurements were made in fractional anisotropy maps in each of 12 white matter regions. Univariate statistics and a two-tailed t test were performed on the raw fractional anisotropy data. Data were then dichotomized using thresholds from univariate statistics. A C-FAST score was devised from the dichotomized data. Logistic regression analyses were performed among the C-FAST, outcome, and predictor data.
RESULTS
Good correlation was noted between the C-FAST and death, hospital stay greater than 10 days, and intensive care unit stay greater than 5 days. Correlation with discharge to rehabilitation facility was good when adjusted for age and sex. Glasgow Coma Scale, revised trauma score, and Abbreviated Injury Scale show good correlation as predictors of a critical C-FAST.
CONCLUSION
The C-FAST is a promising index derived from MRI diffusion fractional anisotropy measurements that shows successful correlation with outcome and predictor variables. A larger investigation is needed to verify the validity and stability of the correlations.
DOI：
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发表时间：
1999-09
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
A. Tievsky;T. Ptak;J. Farkas
通讯作者：
A. Tievsky;T. Ptak;J. Farkas
影响因子：
19.7
作者：
Sorensen, AG;Buonanno, FS;Koroshetz, WJ
通讯作者：
Koroshetz, WJ