Systematic Review of Photodynamic Therapy in Gliomas.
Systematic Review of Photodynamic Therapy in Gliomas.
复制标题
光动力治疗胶质瘤的系统综述。
作者：
恶性胶质瘤是最致命、最难治疗的癌症之一，因为它们具有侵袭性和浸润性以及生长位置的各种特征。光动力学疗法（PDT）是局部癌症治疗的一种有前途的途径。治疗效果是通过全身性药物递送，然后局部波长特定的照明来实现的。这篇综述广泛探讨了光敏剂在胶质瘤中的应用，从它们的第一次使用到现在，并详细介绍了它们的机制，以及临床前和临床发现。进一步讨论了其局限性和未来的发展方向。在过去的20年中，神经胶质瘤占美国人群中恶性CNS肿瘤病例的89%以上（NIH SEER）。其中，胶质母细胞瘤是最常见的亚型，占所有胶质瘤病例的57%。这种致命的疾病具有高度的侵袭性，以其高度的遗传和表型异质性而闻名，导致复杂的病程。目前的标准治疗包括最大限度安全的肿瘤切除术和放化疗。然而，尽管技术和治疗方式取得了进展，但疾病复发率仍然很高，生存率仍然很低。鉴于肿瘤位置的微妙性质，切除后剩余的边缘往往引发疾病复发。光动力疗法（PDT）是一种治疗方式，其在施用无毒光敏剂之后，在局部波长特异性照射后诱导肿瘤特异性抗癌效应。在过去的30年里，人们在临床前和临床试验中广泛研究了它对恶性胶质瘤的作用。在这里，我们对三代光敏剂及其作用机制、局限性和未来发展方向进行了全面综述。
Malignant gliomas are of the deadliest, most hard-to-treat cancers, given their various characteristics of aggression and infiltration as well as the location of growth. Photodynamic therapy (PDT) is a promising avenue for localized cancer therapy. A therapeutic effect is achieved by systemic drug delivery followed by localized wavelength-specific illumination. This review extensively explores the use of photosensitizers in gliomas, from their first use to the present, and details their mechanisms, and pre-clinical and clinical findings. Further discussion is provided on its limitations and future directions. Over the last 20 years, gliomas have made up over 89% of malignant CNS tumor cases in the American population (NIH SEER). Within this, glioblastoma is the most common subtype, comprising 57% of all glioma cases. Being highly aggressive, this deadly disease is known for its high genetic and phenotypic heterogeneity, rendering a complicated disease course. The current standard of care consists of maximally safe tumor resection concurrent with chemoradiotherapy. However, despite advances in technology and therapeutic modalities, rates of disease recurrence are still high and survivability remains low. Given the delicate nature of the tumor location, remaining margins following resection often initiate disease recurrence. Photodynamic therapy (PDT) is a therapeutic modality that, following the administration of a non-toxic photosensitizer, induces tumor-specific anti-cancer effects after localized, wavelength-specific illumination. Its effect against malignant glioma has been studied extensively over the last 30 years, in pre-clinical and clinical trials. Here, we provide a comprehensive review of the three generations of photosensitizers alongside their mechanisms of action, limitations, and future directions.
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影响因子：
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作者：
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DOI：
10.3322/caac.20114
发表时间：
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期刊：
CA: a cancer journal for clinicians
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通讯作者：
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