The association between premature coronary artery disease and level of testosterone in young adult males.
The association between premature coronary artery disease and level of testosterone in young adult males.
复制标题
年轻成年男性早发冠状动脉疾病与睾酮水平之间的关联。
DOI：
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复制
发表时间：
2014
影响因子：
2.1
通讯作者：
Y. Nozari
中科院分区：
文献类型：
--
作者：
Abdulhakim Alkamel;A. Shafiee;A. Jalali;M. Boroumand;Y. Nozari
目标
男性睾酮水平低与心血管疾病风险增加有关。我们的目的是确定年轻成年男性血清睾酮水平与早发冠状动脉疾病 (CAD) 及其预测因子之间的关联。
方法
在这项横断面研究中，纳入了患有不稳定心绞痛、既往无 CAD 且年龄≤ 45 岁且连续接受冠状动脉造影的男性候选者。比较 CAD 阳性和正常冠状动脉受试者的血清游离睾酮 (FT) 和总睾酮 (TT) 水平以及人口统计和心血管特征。低 TT 的截止点为 2.5 ng/L。此外，还评估了所有变量与受影响血管的数量以及 FT 和 TT 以及 CAD 预测因子之间的关系。
结果
In this study, 191 patients with premature CAD were compared with 94 normal coronary subjects. CAD 组患者年龄明显较大（41.59 ± 3.79 岁 vs 39.27 ± 4.97 岁；P 值 < 0.01），并且糖尿病（P 值 = 0.04）和血脂异常（P 值 = 0.01）的发生率较高。 CAD 组的 FT 和 TT 血清水平显着低于正常冠状动脉受试者（两者 P 值均 < 0.01）。低 TT 受试者的比例随受影响血管的数量而增加（趋势 p 值 <0.01），Gensini 评分与 FT 和 TT 之间存在显着相关性（分别为 r = -0.37，P 值 < 0.01 和 r = -0.34，P 值 < 0.01）。调整混杂因素后，低 TT 与 CAD 之间的关联仍然显着（优势比 = 4.30，95% 置信区间：1.99-9.32；P 值 ≤ 0.001） 结论：睾酮水平低与年轻人早发 CAD 及其严重程度相关。
OBJECTIVE
Low testosterone levels in men have been associated with an increased risk of cardiovascular disease. We aimed to identify the association between serum testosterone level and premature coronary artery disease (CAD) and its predictors in young adult males.
METHODS
In this cross sectional study, consecutive male candidates for coronary angiography with unstable angina, no previous CAD and age ≤ 45 years were included. Serum levels of free (FT) and total testosterone (TT) as well as demographic and cardiovascular characteristics were compared between the CAD-positive and normal coronary subjects. The cutoff point for low TT was 2.5 ng/L. Additionally, the relationships between all the variables and the number of affected vessels and FT and TT and predictors of CAD were assessed.
RESULTS
In this study, 191 patients with premature CAD were compared with 94 normal coronary subjects. Patients in the CAD group were significantly older (41.59 ± 3.79 versus 39.27 ± 4.97 years; P-value < 0.01), and had higher rates of diabetes mellitus (P-value = 0.04) and dyslipidemia (P-value = 0.01). Serum levels of FT and TT were significantly lower in the CAD group than the normal coronary subjects (P-value < 0.01 for both). The rate of subjects with low TT increased by the number of the affected vessels (p-value for trend <0.01) and there was a significant correlation between the Gensini score and FT and TT (r = -0.37, P-value < 0.01 and r = -0.34, P-value < 0.01, respectively). After adjustment for confounders, the association between low TT and CAD remained significant (Odds ratio = 4.30, 95% confidence interval: 1.99-9.32; P-value ≤ 0.001) CONCLUSION: Low levels of testosterone were associated with premature CAD and its severity in young adults.
老年男性的生物可利用睾酮和抑郁情绪：兰乔贝尔纳多研究。
DOI：
10.1210/jcem.84.2.5495
发表时间：
1999
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Barrett-Connor,E;VonMuhlen,DG;Kritz-Silverstein,D
通讯作者：
Kritz-Silverstein,D
影响因子：
120.7
作者：
Strong, JP;Malcom, GT;Cornhill, JF
通讯作者：
Cornhill, JF
性激素和年龄：社区男性睾酮和雌二醇及其生物利用度的横断面研究。
影响因子：
5
作者：
Ferrini,RL;Barrett-Connor,E
通讯作者：
Barrett-Connor,E