Factors That May Regulate the Growth and Regression of Blood Vessels in the Ovary

Factors That May Regulate the Growth and Regression of Blood Vessels in the Ovary
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可能调节卵巢血管生长和退化的因素

DOI:
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发表时间:
1983
期刊:
影响因子:
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通讯作者:
W. LeMaire
W. LeMaire
中科院分区:
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文献类型:
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作者:
R. Koos;W. LeMaire

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卵巢的卵泡和黄体是血管丰富的组织,这一事实反映在单位重量的血流速度可能是身体中最高的。这本身并不是独一无二的;其他内分泌组织,如甲状腺、肾上腺皮质和垂体也有丰富的血管床和丰富的血液流动。然而,与身体的其他组织不同,卵泡和黄体是暂时性的结构。例如,一个正在生长的人类卵泡,从它和它的同伴被招募到排卵,生命周期为14天。2绝大多数卵泡并不经历整个发育过程,而是在发育的某个阶段变得闭锁。排卵后,黄体从破裂的卵泡形成,但除非怀孕,否则大约14天后黄体会退化。在平均生殖寿命中,人类卵巢可以经历多达500个这样的发育周期。卵泡和黄体的寿命随物种的不同而不同,但在所有情况下,这些结构都经历了动态增长期和退化期。卵泡和黄体生长的一个必需部分是滋养这些代谢活性组织的血管网络的生长。相反,卵泡闭锁和黄体退化伴随着
The follicle and corpus luteum of the ovary are richly vascularized tissues, a fact reflected by blood flow rates per unit weight that are perhaps the highest in the body. 1 This is not in itself unique; other endocrine tissues such as the thy roid, adrenal cortex, and pituitary also have rich vascular beds and abundant blood flow. Unlike other tissues in the body, however, the follicle and corpus luteum are transient structures. A growing human follicle, for instance, has a life span of 14 days from the time it and its cohorts are recruited until it ovulates. 2 The vast majority of follicles do not go through the entire developmental sequence but become atretic at some stage of development. After ovulation, the corpus luteum forms from the ruptured follicle but undergoes regression after about 14 days unless pregnancy occurs. During the average re productive lifespan, the human ovary could go through as many as 500 such developmental cy cles. Lifespans of the follicle and corpus luteum vary from species to species, but in all cases these structures undergo periods of dynamic growth followed by regression. An obligatory part of the growth of the follicle and corpus luteum is the growth of the vascular network that nourishes these metabolically ac tive tissues. Conversely, follicular atresia and corpus luteum regression are accompanied by
DOI: 10.1210/endo-109-2-356
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期刊: Endocrinology
影响因子: 4.8
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DOI: 10.1016/s0015-0282(16)46763-4
发表时间: 1983
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