Defining the nuanced nature of redox biology in post-traumatic stress disorder.
Defining the nuanced nature of redox biology in post-traumatic stress disorder.
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DOI：
10.3389/fphys.2023.1130861
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发表时间：
2023
影响因子：
4
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创伤后应激障碍（PTSD）是一种在经历或目睹创伤事件后出现的心理健康障碍。尽管影响了大约7%的人口，但目前还没有明确的生物学特征或生物标志物用于诊断PTSD。因此，寻找临床相关和可重复的生物标志物一直是该领域的主要焦点。随着包括基因组学、蛋白质组学和代谢组学数据在内的大规模多组学研究的重大进展，已经取得了有希望的发现，但该领域仍然存在不足。在可能的生物标志物检查，一个领域往往被忽视，研究不足，或不适当的调查：氧化还原生物学领域。氧化还原分子是自由基和/或活性物质，其是由于生命的电子运动的必要性而产生的。这些活性分子也是生命所必需的，但过量则被称为“氧化应激”，通常与许多疾病有关。研究氧化还原生物学参数的少数研究经常使用过时的和非特异性的方法，并报告了混淆的结果，这使得很难得出结论氧化还原在PTSD中的作用。在此，我们提供了氧化还原生物学如何成为PTSD等疾病的基础，严格检查PTSD的氧化还原研究，并提供该领域可以实施的未来方向，以提高氧化还原评估的标准化，可重复性和准确性，用于诊断，预后和治疗这种使人衰弱的心理健康障碍。
Post-traumatic stress disorder (PTSD) is a mental health disorder that arises after experiencing or witnessing a traumatic event. Despite affecting around 7% of the population, there are currently no definitive biological signatures or biomarkers used in the diagnosis of PTSD. Thus, the search for clinically relevant and reproducible biomarkers has been a major focus of the field. With significant advances of large-scale multi-omic studies that include genomic, proteomic, and metabolomic data, promising findings have been made, but the field still has fallen short. Amongst the possible biomarkers examined, one area is often overlooked, understudied, or inappropriately investigated: the field of redox biology. Redox molecules are free radical and/or reactive species that are generated as a consequence of the necessity of electron movement for life. These reactive molecules, too, are essential for life, but in excess are denoted as “oxidative stress” and often associated with many diseases. The few studies that have examined redox biology parameters have often utilized outdated and nonspecific methods, as well as have reported confounding results, which has made it difficult to conclude the role for redox in PTSD. Herein, we provide a foundation of how redox biology may underlie diseases like PTSD, critically examine redox studies of PTSD, and provide future directions the field can implement to enhance standardization, reproducibility, and accuracy of redox assessments for the use of diagnosis, prognosis, and therapy of this debilitating mental health disorder.
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