Long-term follow-up of HLA-A2+ patients with high-risk, hormone-sensitive prostate cancer vaccinated with the prostate specific antigen peptide homologue (PSA146-154).
Long-term follow-up of HLA-A2+ patients with high-risk, hormone-sensitive prostate cancer vaccinated with the prostate specific antigen peptide homologue (PSA146-154).
复制标题
DOI：
10.1155/2010/473453
复制
发表时间：
2010
影响因子：
--
通讯作者：
Peace DJ
中科院分区：
文献类型：
--
作者：
Perambakam S;Xie H;Edassery S;Peace DJ
在2002年7月至2004年9月期间，28例HLA-A2阳性的高风险、局部晚期或转移性激素敏感前列腺癌患者接种了一种前列腺特异性抗原PSA146-154的肽同源物，并监测了临床和免疫反应。50%的患者在一年内出现强烈的psa146 -154肽特异性延迟型过敏皮肤反应，四聚体和/或IFN-γ反应。13例患者在接种疫苗一年后血清PSA水平稳定或下降。与接种前水平相比，6个月时四聚体反应增强的患者生化进展风险降低（P = 0.02）。根据Kaplan-Meier分析，13例患者死亡，15例患者存活，平均总生存期为60个月（95% CI， 51至68个月）。在接种PSA146-154肽后产生特异性t细胞免疫的高危、激素敏感的CaP患者中，发现了总体生存率更高的趋势。
Twenty-eight HLA-A2+ patients with high-risk, locally advanced or metastatic, hormone-sensitive prostate cancer were immunized with a peptide homologue of prostate-specific antigen, PSA146-154, between July 2002 and September 2004 and monitored for clinical and immune responses. Fifty percent of the patients developed strong PSA146-154-peptide-specific delayed-type hypersensitivity skin responses, tetramer and/or IFN-γ responses within one year. Thirteen patients had stable or declining serum levels of PSA one year post-vaccination. A decreased risk of biochemical progression was observed in patients who developed augmented tetramer responses at six months compared to pre-vaccination levels (P = .02). Thirteen patients have died while 15 patients remain alive with a mean overall survival of 60 months (95% CI, 51 to 68 months) per Kaplan-Meier analysis. A trend towards greater overall survival was detected in men with high-risk, hormone-sensitive CaP who developed specific T-cell immunity following vaccination with PSA146-154 peptide.
登录
查看更多内容
影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
DOI：
10.1084/jem.190.11.1669
发表时间：
1999-12-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Thurner B;Haendle I;Röder C;Dieckmann D;Keikavoussi P;Jonuleit H;Bender A;Maczek C;Schreiner D;von den Driesch P;Bröcker EB;Steinman RM;Enk A;Kämpgen E;Schuler G
通讯作者：
Schuler G
影响因子：
6.2
作者：
Higano, Celestia S.;Schellhammer, Paul F.;Frohlich, Mark W.
通讯作者：
Frohlich, Mark W.
影响因子：
5.8
作者：
Perambakam, Supriya;Hallmeyer, Sigrun;Peace, David J.
通讯作者：
Peace, David J.
影响因子：
82.9
作者：
Nestle, FO;Alijagic, S;Schadendorf, D
通讯作者：
Schadendorf, D