Early detection of secondary damage in ipsilateral thalamus after acute infarction at unilateral corona radiata by diffusion tensor imaging and magnetic resonance spectroscopy.
Early detection of secondary damage in ipsilateral thalamus after acute infarction at unilateral corona radiata by diffusion tensor imaging and magnetic resonance spectroscopy.
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弥散张量成像和磁共振波谱早期检测单侧放射冠急性梗死后同侧丘脑继发性损伤
DOI：
10.1186/1471-2377-11-49
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发表时间：
2011-05-05
期刊：
影响因子：
2.6
通讯作者：
Zeng J
中科院分区：
文献类型：
--
作者：
Li C;Ling X;Liu S;Xu A;Zhang Y;Xing S;Pei Z;Zeng J
传统的磁共振（MR）成像可以识别单侧大脑中动脉（MCA）梗死患者同侧丘脑的异常变化。然而，很难定量地证明这些早期的变化。扩散张量成像（DTI）和质子磁共振波谱（MRS）是检测组织微观结构和代谢变化的潜在敏感和定量的检测方法。在这项研究中，我们使用DTI和MRS检查放射状冠梗死患者丘脑可能的继发性损伤。方法12例单侧冠状辐射性脑梗死患者分别于脑卒中发病后1周（W1）、4周（W4）、12周（W12）行DTI和MRS影像学检查。对12名年龄匹配的对照组进行成像。测定丘脑平均扩散率（MD）、分数各向异性（FA）、n -乙酰天冬氨酸（NAA）、胆碱（Cho）和肌酸（Cr）。结果st1加权液体衰减反转恢复（FLAIR）、t2加权和T2-FLAIR成像均显示单侧冠状辐射处有梗死，无其他病变。在患者中，与W1和W4相比，W12时MD显著增加（均p < 0.05）。同侧丘脑NAA在W4时较W1显著降低，在W12时较W4显著降低（p < 0.05）。从W1到W12，同侧丘脑FA、Cho或Cr无显著变化。Spearman秩相关分析显示，MD与W1、W4、W12时NAA、Cho、Cr峰面积呈显著负相关，FA与W1时NAA峰面积呈显著正相关。结论DTI和MRS可检测单侧放射状冠梗死后同侧丘脑继发性损伤的早期变化。MRS可以显示同侧丘脑损伤随时间的进展过程。
BackgroundTraditional magnetic resonance (MR) imaging can identify abnormal changes in ipsilateral thalamus in patients with unilateral middle cerebral artery (MCA) infarcts. However, it is difficult to demonstrate these early changes quantitatively. Diffusion tensor imaging (DTI) and proton magnetic resonance spectroscopy (MRS) are potentially sensitive and quantitative methods of detection in examining changes of tissue microstructure and metabolism. In this study, We used both DTI and MRS to examine possible secondary damage of thalamus in patients with corona radiata infarction.MethodsTwelve patients with unilateral corona radiata infarction underwent MR imaging including DTI and MRS at one week (W1), four weeks (W4), and twelve weeks (W12) after onset of stroke. Twelve age-matched controls were imaged. Mean diffusivity (MD), fractional anisotropy (FA), N-acetylaspartate (NAA), choline(Cho), and creatine(Cr) were measured in thalami.ResultsT1-weighted fluid attenuation inversion recovery (FLAIR), T2-weighted, and T2-FLAIR imaging showed an infarct at unilateral corona radiate but no other lesion in each patient brain. In patients, MD was significantly increased at W12, compared to W1 and W4 (allP< 0.05). NAA was significantly decreased at W4 compared to W1, and at W12 compared to W4 (allP< 0.05) in the ipsilateral thalamus. There was no significant change in FA, Cho, or Cr in the ipsilateral thalamus from W1 to W12. Spearman's rank correlation analysis revealed a significant negative correlation between MD and the peak area of NAA, Cho, and Cr at W1, W4, and W12 and a significant positive correlation of FA with NAA at W1.ConclusionsThese findings indicate that DTI and MRS can detect the early changes indicating secondary damage in the ipsilateral thalamus after unilateral corona radiata infarction. MRS may reveal the progressive course of damage in the ipsilateral thalamus over time.
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影响因子：
8.3
作者：
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通讯作者：
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