Neuroscience of alcoholism: molecular and cellular mechanisms.
Neuroscience of alcoholism: molecular and cellular mechanisms.
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DOI：
10.1007/s00018-009-0135-y
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发表时间：
2010-01
影响因子：
8
通讯作者：
Pandey, Subhash C.
中科院分区：
文献类型：
--
作者：
Moonat, Sachin;Starkman, Bela G.;Sakharkar, Amul;Pandey, Subhash C.
酒精的使用和滥用似乎与功能，神经化学和结构水平的神经适应性变化有关。急性和慢性乙醇暴露已被证明可以调节大脑中活性依赖性基因转录因子cAMP反应元件结合（CREB）蛋白的功能，这可能与酒精中毒的发展有关。对CREB下游效应子的研究已经确定了几个重要的CREB相关基因，如神经肽Y、脑源性神经营养因子、活性调节的细胞因子相关蛋白和促肾上腺皮质激素释放因子，这些基因可能在乙醇的行为效应和特定神经回路的分子变化中发挥关键作用，这些神经回路是酒精成瘾和酒精中毒遗传易感性的基础。由于组蛋白共价修饰引起的脑染色质重塑也可能参与介导乙醇暴露期间发生的行为效应和神经适应性变化。本文综述了神经科学对酒精中毒的分子和表观遗传机制的研究进展。
Alcohol use and abuse appear to be related to neuroadaptive changes at functional, neurochemical, and structural levels. Acute and chronic ethanol exposure have been shown to modulate function of the activity-dependent gene transcription factor, cAMP-responsive element binding (CREB) protein in the brain, which may be associated with the development of alcoholism. Study of the downstream effectors of CREB have identified several important CREB-related genes, such as neuropeptide Y, brain-derived neurotrophic factor, activity-regulated cytoskeleton-associated protein, and corticotrophin-releasing factor, that may play a crucial role in the behavioral effects of ethanol and molecular changes in the specific neurocircuitry that underlie both alcohol addiction and a genetic predisposition to alcoholism. Brain chromatin remodeling due to histone covalent modifications may also be involved in mediating the behavioral effects and neuroadaptive changes that occur during ethanol exposure. This review outlines progressive neuroscience research into molecular and epigenetic mechanisms of alcoholism.
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DOI：
10.1073/pnas.0802302105
发表时间：
2008-06-17
影响因子：
11.1
作者：
Bajo, Michal;Cruz, Maureen T.;Roberto, Marisa
通讯作者：
Roberto, Marisa
影响因子：
4.8
作者：
Constantinescu, A;Diamond, I;Gordon, AS
通讯作者：
Gordon, AS
影响因子：
4.4
作者：
Acquaah-Mensah GK;Misra V;Biswal S
通讯作者：
Biswal S
影响因子：
2.9
作者：
Chance, WT;Sheriff, S;Balasubramaniam, A
通讯作者：
Balasubramaniam, A
影响因子：
5.3
作者：
Conway, KP;Compton, W;Grant, BF
通讯作者：
Grant, BF