The value of T(2) (*)-weighted gradient echo imaging for detection of familial cerebral cavernous malformation: A study of two families.
The value of T(2) (*)-weighted gradient echo imaging for detection of familial cerebral cavernous malformation: A study of two families.
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T2*加权梯度回波成像检测家族性脑海绵状血管瘤的价值：两个家系的研究
DOI：
10.3892/etm.2012.845
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发表时间：
2013-02
影响因子：
2.7
通讯作者：
Wang SJ
中科院分区：
文献类型：
--
作者：
Liu XW;Wang SH;Chi ZF;Su LJ;Zhao XH;Wang SJ
本研究旨在探讨T2*加权梯度回波成像（GRE T2*-WI）对家族性脑海绵状畸形（FCCM）的检测价值。采用计算机断层扫描（CT）、常规磁共振成像（MRI）和GRE T2*-WI序列对2个FCCM家族的26名成员进行检查。我们通过GRE T2*-WI序列鉴定了12例FCCM。12例患者有多发病变（平均23例）。病变最常见于神经节。其他区域包括皮层-下皮层、丘脑、小脑和脑干。这些病变表现为网状核心，信号强度混合，周围边缘信号强度降低，代表先前出血的含铁血黄素。各种常规MRI序列检测到的FCCM的平均病变数和病例数分别为5-17和3-9。常规MRI检查依次为t1加权成像（T1WI）、t2加权成像（T2WI）、t2流体衰减反演恢复（T2Flair）、扩散加权成像（DWI）和自旋回波成像（SE）序列。MRI发现的病变数量少于GRE T2*-WI。CT仅发现3例大病变合并出血和钙化。以上结果提示，与CT和常规MRI相比，GRE T2*-WI是诊断FCCM的首选。
The aim of this study was to investigate the value of T2*-weighted gradient echo imaging (GRE T2*-WI) for the detection of familial cerebral cavernous malformation (FCCM). Twenty-six members of 2 families with FCCM were examined using computed tomography (CT), conventional magnetic resonance imaging (MRI) and GRE T2*-WI sequences. We identified 12 cases of FCCM using GRE T2*-WI sequences. These 12 patients had multiple lesions (mean 23). The lesions were most commonly located in the ganglia. Other areas included the cortex-subcortex, thalamus, cerebellum and brainstem. These lesions appeared as a reticulated core of mixed signal intensity with a surrounding rim of decreased signal intensity representing hemosiderin from previous hemorrhages. The mean numbers of lesions and cases of FCCM identified by various conventional MRI sequences were 5–17 and 3–9, respectively. Conventional MRI examination involved T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), T2-fluid-attenuated inversion recovery (T2Flair), diffusion-weighted imaging (DWI) and spin-echo imaging (SE) sequences, in that order. The numbers of lesions identified by MRI were fewer than those identified by GRE T2*-WI. CT only identified 3 cases with large lesions combined with hemorrhage and calcification. These findings suggest that GRE T2*-WI is the first choice when diagnosing FCCM compared with CT and conventional MRI.
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影响因子：
158.5
作者：
Gunel, M;Awad, IA;Lifton, RP
通讯作者：
Lifton, RP
影响因子：
4.1
作者：
ROBINSON, JR;AWAD, IA;LITTLE, JR
通讯作者：
LITTLE, JR
影响因子：
9.8
作者：
Denier, C;Goutagny, S;Tournier-Lasserve, E
通讯作者：
Tournier-Lasserve, E
影响因子：
2.9
作者：
Chi, Ling-Yi;Wang, Shu-Hua;Wang, Xiao-Hua
通讯作者：
Wang, Xiao-Hua
影响因子：
4.8
作者：
Ohue, Shiro;Fukushima, Takanori;Ohnishi, Takanori
通讯作者：
Ohnishi, Takanori