Effect of the Maximum Dose on White Matter Fiber Bundles Using Longitudinal Diffusion Tensor Imaging.
Effect of the Maximum Dose on White Matter Fiber Bundles Using Longitudinal Diffusion Tensor Imaging.
复制标题
使用纵向扩散张量成像最大剂量对白质纤维束的影响。
DOI：
10.1016/j.ijrobp.2016.07.010
复制
发表时间：
2016-11-01
影响因子：
7
通讯作者：
Cao, Yue
中科院分区：
文献类型：
--
作者：
Zhu, Tong;Chapman, Christopher H.;Tsien, Christina;Kim, Michelle;Spratt, Daniel E.;Lawrence, Theodore S.;Cao, Yue
Previous efforts to decrease neurocognitive effects of radiation focused on sparing isolated cortical structures. We hypothesize that understanding temporal, spatial and dosimetric patterns of radiation damage of whole brain white matter (WBWM) after partial brain irradiation might also be important. Therefore, we carried out a study to develop the methodology to assess radiotherapy-induced damage to WBWM bundles. An atlas-based, automated WM tractography analysis was implemented to quantify longitudinal changes in indices of diffusion tensor imaging (DTI) of 22 major WM fibers in 33 patients with predominantly low-grade/benign brain tumors treated by radiotherapy. Six DTI scans per patient were performed from pre-RT to 18 months post-RT. The DTI indices and planned doses (maximum and mean doses) were mapped onto profiles of each of 22 WM bundles. A multivariate linear regression was performed to determine the main dose effect as well as the influence of other clinical factors on longitudinal percentage changes in axial and radial diffusivity (AD and RD) from pre-RT. Of 22 fiber bundles, AD/RD changes in 12 bundles were affected significantly by doses (P<0.05), as the effect was progressive over time. In nine elongated tracts, decreased AD/RD was significantly related to maximum doses received, consistent with a serial-structure. In individual bundles, AD changes were up to 11.5% at the maximum dose locations 18 months post-RT. The dose effect on WM was greater in older females than younger males. Our study demonstrates for the first time that the maximum dose to the elongated WM bundles causes post-radiotherapy damage in WM. Validation and correlative studies are necessary to determine the ability and impact of sparing these bundles on preserving neurocognitive function post-radiotherapy.
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DOI：
10.1158/1078-0432.ccr-11-2903
发表时间：
2013-05-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Greene-Schloesser D;Moore E;Robbins ME
通讯作者：
Robbins ME
影响因子：
3.7
作者：
Chapman CH;Nazem-Zadeh M;Lee OE;Schipper MJ;Tsien CI;Lawrence TS;Cao Y
通讯作者：
Cao Y
影响因子：
4.7
作者：
Greene-Schloesser D;Robbins ME;Peiffer AM;Shaw EG;Wheeler KT;Chan MD
通讯作者：
Chan MD
DOI：
10.1016/j.ijrobp.2015.08.014
发表时间：
2015-11-15
影响因子：
7
作者：
Farjam, Reza;Pramanik, Priyanka;Cao, Yue
通讯作者：
Cao, Yue
影响因子：
3.5
作者：
Nazem-Zadeh, Mohammad-Reza;Chapman, Christopher H.;Cao, Yue
通讯作者：
Cao, Yue