Approaches towards fighting the COVID‑19 pandemic (Review).
Approaches towards fighting the COVID‑19 pandemic (Review).
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DOI：
10.3892/ijmm.2020.4794
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发表时间：
2021-01
影响因子：
5.4
通讯作者：
Yang JS
中科院分区：
文献类型：
--
作者：
Tsai SC;Lu CC;Bau DT;Chiu YJ;Yen YT;Hsu YM;Fu CW;Kuo SC;Lo YS;Chiu HY;Juan YN;Tsai FJ;Yang JS
The coronavirus disease 2019 (COVID-19) outbreak, which has caused >46 millions confirmed infections and >1.2 million coronavirus related deaths, is one of the most devastating worldwide crises in recent years. Infection with COVID-19 results in a fever, dry cough, general fatigue, respiratory symptoms, diarrhoea and a sore throat, similar to those of acute respiratory distress syndrome. The causative agent of COVID-19, SARS-CoV-2, is a novel coronavirus strain. To date, remdesivir has been granted emergency use authorization for use in the management of infection. Additionally, several efficient diagnostic tools are being actively developed, and novel drugs and vaccines are being evaluated for their efficacy as therapeutic agents against COVID-19, or in the prevention of infection. The present review highlights the prevalent clinical manifestations of COVID-19, characterizes the SARS-CoV-2 viral genome sequence and life cycle, highlights the optimal methods for preventing viral transmission, and discusses possible molecular pharmacological mechanisms and approaches in the development of anti-SARS-CoV-2 therapeutic agents. In addition, the use of traditional Chinese medicines for management of COVID-19 is discussed. It is expected that novel anti-viral agents, vaccines or an effective combination therapy for treatment/management of SARS-CoV-2 infection and spread therapy will be developed and implemented in 2021, and we would like to extend our best regards to the frontline health workers across the world in their fight against COVID-19.
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影响因子：
30.8
作者：
Chan VS;Chan KY;Chen Y;Poon LL;Cheung AN;Zheng B;Chan KH;Mak W;Ngan HY;Xu X;Screaton G;Tam PK;Austyn JM;Chan LC;Yip SP;Peiris M;Khoo US;Lin CL
通讯作者：
Lin CL
影响因子：
5.7
作者：
Chan, Kam Wa;Wong, Vivian Taam;Tang, Sydney Chi Wai
通讯作者：
Tang, Sydney Chi Wai
影响因子：
5.4
作者：
Chen, Wen-Hsiang;Strych, Ulrich;Bottazzi, Maria Elena
通讯作者：
Bottazzi, Maria Elena
影响因子：
6.4
作者：
Angelini MM;Akhlaghpour M;Neuman BW;Buchmeier MJ
通讯作者：
Buchmeier MJ
影响因子：
12.8
作者：
Clancy RM;Markham AJ;Reed JH;Blumenberg M;Halushka MK;Buyon JP
通讯作者：
Buyon JP