Drug certainty-response in interview-based studies.
Drug certainty-response in interview-based studies.
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DOI：
10.1002/pds.2234
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发表时间：
2011-11
影响因子：
2.6
通讯作者：
Hernandez-Diaz, Sonia
中科院分区：
文献类型：
--
作者：
Yau, Wai-Ping;Lin, Kueiyu Joshua;Werler, Martha M.;Louik, Carol;Mitchell, Allen A.;Hernandez-Diaz, Sonia
暴露时间的不完美回忆挑战了基于访谈的研究中的药物确定。我们提出了一种算法来分类药物暴露考虑召回的确定性。药物使用详细信息的可用性，包括使用持续时间、开始和停止日期以及母亲对这些日期的确定程度的估计，允许将受试者分类为可能或可能在妊娠前三个月暴露。我们应用该算法研究了产前四环素暴露与国家出生缺陷预防研究先前报告的先天性心脏缺陷风险之间的关联，使用了1993-2008年斯隆流行病学中心出生缺陷研究中11517名受试者的数据。在妊娠期间暴露于四环素类药物的女性中（n = 58），50%可能在妊娠早期暴露，19%可能在妊娠早期暴露; 31%在妊娠早期以外暴露。与妊娠期间未使用相比，妊娠早期以外暴露的粗比值比（OR）为1.0（95%置信区间0.4-2.5）;对于暴露（可能或可能合并）在前三个月是1.7（0.9-3.2）;然而，基于算法的OR为0.9（0.3-3.0）（可能暴露）和2.2（1.0-4.6）（可能暴露）。在病因学关注窗口内的暴露中发现了“确定性反应”（与更高确定性水平的更强关联）。结合回忆确定性的暴露分类算法可能在基于访谈的研究中有用。
Imperfect recall of exposure timing challenges the ascertainment of medications in interview-based studies. We propose an algorithm to classify medication exposure taking into account recall certainty. The availability of medication use details, including duration of use, start and stop dates, and maternal estimates of how certain they were about these dates, allowed classification of subjects as either likely or possibly exposed in the first trimester of pregnancy. We applied the algorithm to study an association between prenatal tetracycline exposure and risk of congenital heart defects previously-reported by the National Birth Defects Prevention Study, using 1993–2008 data from 11 517 subjects in the Slone Epidemiology Center Birth Defects Study. Among women exposed to tetracyclines during pregnancy (n = 58), 50% were likely and 19% possibly exposed in the first trimester; and 31% exposed outside the first trimester. Compared to nonuse during pregnancy, the crude odds ratio (OR) for exposure outside the first trimester was 1.0 (95% confidence interval 0.4–2.5); for exposed (likely or possibly, combined) in the first trimester it was 1.7 (0.9–3.2); however, the ORs based on the algorithms were 0.9 (0.3–3.0) for possibly exposed and 2.2 (1.0–4.6) for likely exposed. A ‘certainty-response’ (stronger association with higher level of certainty) was found within exposures in the window of etiological interest. Algorithms for exposure classification that incorporate recall certainty may be useful in interview-based studies.
DOI：
10.1001/archpediatrics.2009.188
发表时间：
2009-11-01
影响因子：
--
作者：
Crider, Krista S.;Cleves, Mario A.;Hu, Dale J.
通讯作者：
Hu, Dale J.
影响因子：
5
作者：
MITCHELL, AA;COTTLER, LB;SHAPIRO, S
通讯作者：
SHAPIRO, S