Long-Lived Plasma Cells in Mice and Men.
Long-Lived Plasma Cells in Mice and Men.
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DOI：
10.3389/fimmu.2018.02673
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发表时间：
2018
影响因子：
7.3
通讯作者：
Grimsholm O
中科院分区：
文献类型：
--
作者：
Brynjolfsson SF;Persson Berg L;Olsen Ekerhult T;Rimkute I;Wick MJ;Mårtensson IL;Grimsholm O
尽管天花已被根除30多年，但在儿童时期接种疫苗的受试者血液中仍可检测到高滴度的天花特异性抗体。事实上，血清中的天花特异性抗体水平可维持70多年。对天花和麻疹等传染病产生终身免疫的过程已得到全面记录。尽管在没有病原体的情况下，高持续抗体滴度背后的机制尚不清楚，但长寿浆细胞（llpc）发挥了重要作用。目前大多数关于llpc的知识都是基于在小鼠模型中进行的实验，尽管来自人类研究的数据量正在增加。由于小鼠模型的结果通常直接外推到人类身上，因此重要的是要记住存在差异。这不仅是寿命等明显的差异，而且还有解剖学上的差异，例如llpc所在的骨髓（BM）的肥胖程度。这些差异是否对免疫系统的功能，特别是对llpc的功能有影响，目前尚不清楚。在这篇综述中，我们将简要讨论LLPCs的现有知识，并比较小鼠和人类。
Even though more than 30 years have passed since the eradication of smallpox, high titers of smallpox-specific antibodies are still detected in the blood of subjects vaccinated in childhood. In fact, smallpox-specific antibody levels are maintained in serum for more than 70 years. The generation of life-long immunity against infectious diseases such as smallpox and measles has been thoroughly documented. Although the mechanisms behind high persisting antibody titers in the absence of the causative agent are still unclear, long lived plasma cells (LLPCs) play an important role. Most of the current knowledge on LLPCs is based on experiments performed in mouse models, although the amount of data derived from human studies is increasing. As the results from mouse models are often directly extrapolated to humans, it is important to keep in mind that there are differences. These are not only the obvious such as the life span but there are also anatomical differences, for instance the adiposity of the bone marrow (BM) where LLPCs reside. Whether these differences have an effect on the function of the immune system, and in particular on LLPCs, are still unknown. In this review, we will briefly discuss current knowledge of LLPCs, comparing mice and humans.
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影响因子：
5.4
作者：
Bortnick, Alexandra;Chernova, Irene;Allman, David
通讯作者：
Allman, David
影响因子：
7.5
作者：
Brynjolfsson, Siggeir F.;Mohaddes, Maziar;Wick, Mary-Jo
通讯作者：
Wick, Mary-Jo
DOI：
10.1073/pnas.81.8.2475
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
BUTLER, JL;FALKOFF, RJM;FAUCI, AS
通讯作者：
FAUCI, AS
影响因子：
32.4
作者：
Halliley JL;Tipton CM;Liesveld J;Rosenberg AF;Darce J;Gregoretti IV;Popova L;Kaminiski D;Fucile CF;Albizua I;Kyu S;Chiang KY;Bradley KT;Burack R;Slifka M;Hammarlund E;Wu H;Zhao L;Walsh EE;Falsey AR;Randall TD;Cheung WC;Sanz I;Lee FE
通讯作者：
Lee FE
影响因子：
16.6
作者：
Bohannon, Caitlin;Powers, Ryan;Jacob, Joshy
通讯作者：
Jacob, Joshy