Prospective serum metabolomic profile of prostate cancer by size and extent of primary tumor.
Prospective serum metabolomic profile of prostate cancer by size and extent of primary tumor.
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DOI：
10.18632/oncotarget.16775
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发表时间：
2017-07-11
期刊：
影响因子：
--
通讯作者：
Albanes D
中科院分区：
文献类型：
--
作者：
Huang J;Mondul AM;Weinstein SJ;Karoly ED;Sampson JN;Albanes D
最近的两项研究发现，血清脂质和能量代谢产物与侵袭性前列腺癌在确诊前长达20年的时间有关。为了阐明这些代谢特征是否代表病因学或肿瘤生物标志物信号，我们在ATBC研究队列中根据原发肿瘤的大小和范围前瞻性地检查了前列腺癌患者的血清代谢物，并将诊断为T2(n=71)、T3(n=51)或T4(n=15)的病例与对照组(n=200)进行了比较。从空腹血清采集到诊断的时间1-20年，平均10年。LC/MS-GC/MS鉴定了625种已知化合物，Logistic回归估计了与对数代谢物的一个标准差相关的优势比(OR)。T2癌患者血清N-乙酰基-3-甲基组氨酸、3-甲基组氨酸和2‘-脱氧尿苷较对照组升高(ORs=1.38~1.79；0.0002≤p≤0.01)。相反，4种脂代谢产物与T3肿瘤呈负相关：油酰亚油酰甘油磷脂(GPI)、棕榈酰亚油酰甘油磷脂(GPI)、胆酸盐和肌醇1-磷酸(ORS=0.49~0.60；0.000017≤p≤0.003)。在被诊断为T4癌症的男性中，次级胆汁酸脂、性类固醇和咖啡因相关的黄嘌呤代谢物升高，而两种Krebs循环代谢物减少。初发前列腺癌T2、T3和T4的患者在确诊前几年表现出不同的代谢产物，可能代表病因、反映不同原发肿瘤的分子模式，或两者兼而有之。
Two recent investigations found serum lipid and energy metabolites related to aggressive prostate cancer up to 20 years prior to diagnosis. To elucidate whether those metabolomic profiles represent etiologic or tumor biomarker signals, we prospectively examined serum metabolites of prostate cancer cases by size and extent of primary tumors in a nested case-control analysis in the ATBC Study cohort that compared cases diagnosed with T2 (n = 71), T3 (n = 51), or T4 (n = 15) disease to controls (n = 200). Time from fasting serum collection to diagnosis averaged 10 years (range 1–20). LC/MS-GC/MS identified 625 known compounds, and logistic regression estimated odds ratios (ORs) associated with one-standard deviation differences in log-metabolites. N-acetyl-3-methylhistidine, 3-methylhistidine and 2′-deoxyuridine were elevated in men with T2 cancers compared to controls (ORs = 1.38–1.79; 0.0002 ≤ p ≤ 0.01). By contrast, four lipid metabolites were inversely associated with T3 tumors: oleoyl-linoleoyl-glycerophosphoinositol (GPI), palmitoyl-linoleoyl-GPI, cholate, and inositol 1-phosphate (ORs = 0.49–0.60; 0.000017 ≤ p ≤ 0.003). Secondary bile acid lipids, sex steroids and caffeine-related xanthine metabolites were elevated, while two Krebs cycle metabolites were decreased, in men diagnosed with T4 cancers. Men with T2, T3, and T4 prostate cancer primaries exhibit qualitatively different metabolite profiles years in advance of diagnosis that may represent etiologic factors, molecular patterns reflective of distinct primary tumors, or a combination of both.
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影响因子：
37.8
作者：
Cheng S;Rhee EP;Larson MG;Lewis GD;McCabe EL;Shen D;Palma MJ;Roberts LD;Dejam A;Souza AL;Deik AA;Magnusson M;Fox CS;O'Donnell CJ;Vasan RS;Melander O;Clish CB;Gerszten RE;Wang TJ
通讯作者：
Wang TJ
影响因子：
5
作者：
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通讯作者：
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影响因子：
9.7
作者：
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通讯作者：
Kim, ND
DOI：
10.1080/01635581.2015.1004727
发表时间：
2015-04-03
影响因子：
2.9
作者：
Liu, Huan;Hu, Guang-Hui;Xu, Yun-Fei
通讯作者：
Xu, Yun-Fei
影响因子：
3.7
作者：
Kurland IJ;Broin PÓ;Golden A;Su G;Meng F;Liu L;Mohney R;Kulkarni S;Guha C
通讯作者：
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