Heterogeneous Cross‐Linking and Sulphation of Chitosan
Heterogeneous Cross‐Linking and Sulphation of Chitosan
复制标题
壳聚糖的多相交联和硫酸化
DOI：
10.1002/masy.201400067
复制
发表时间：
2014
影响因子：
--
通讯作者：
Jäger
中科院分区：
文献类型：
--
作者：
Höhne;Breier;Jäger
壳聚糖纺织支架是用于组织工程的新型有前途的生物材料。在壳聚糖分子中引入硫酸基团导致生物材料结合了两个重要特征。首先，它是构建组织工程支架的优异材料，其次，它能够模拟天然硫酸多糖与生长因子的有益相互作用。为溶液中壳聚糖的硫酸化（均相反应）而开发的已知硫酸化方法适用于将它们应用于固体壳聚糖表面（非均相反应）。防止壳聚糖溶解的表面反应对于在衍生反应过程中保持支架预定的几何结构至关重要。对壳聚糖颗粒和壳聚糖纺织品进行了模型研究。感兴趣的点是硫酸化反应的区域选择性的控制和硫酸化程度的调整。结果表明，壳聚糖的部分交联是在随后的硫酸化反应过程中保持壳聚糖颗粒和纤维几何结构的关键工具。通过X射线光电子能谱和元素分析对改性样品进行了全面表征。
Chitosan textile scaffolds are novel promising biomaterials for application in tissue engineering. The introduction of sulphate groups in the chitosan molecule leads to a biomaterial that combines two important features. At first it's an excellent material in order to build scaffolds for tissue engineering, and at second it is able to mimic the beneficial interaction of natural occurring sulphated polysaccharides with growth factors. Known sulphating methods, developed for the sulphation of chitosan in solutions (homogeneous phase reactions), were adapted to apply them on solid chitosan surfaces (heterogeneous phase reactions). Surface reactions preventing the chitosan's dissolution were fundamentally necessary to keep the predetermined geometric structure of the scaffolds during derivatization reactions. Model studies were carried out on chitosan particles as well as chitosan textiles. Points of interests were the control of the regioselectivity of the sulphation reactions and the adjustment of the degree of sulphation. It was shown that a partial cross‐linking of chitosan is a key tool to keep the geometric structure of the chitosan particles and fibres during the subsequent sulphation reaction. The modified samples were comprehensively characterized by means of X‐ray photoelectron spectroscopy and elemental analysis.
登录
查看更多内容
不同取代区域羧甲基磺基壳聚糖的制备
DOI：
--
发表时间：
2003
期刊：
影响因子：
--
作者：
Z. Xia;Z. Lv;Jiamin Xu;Guangli Yu
通讯作者：
Guangli Yu
影响因子：
9.7
作者：
Peschel, D.;Zhang, K.;Groth, T.
通讯作者：
Groth, T.
影响因子：
6.2
作者：
Hintze, Vera;Samsonov, Sergey A.;Pisabarro, M. Teresa
通讯作者：
Pisabarro, M. Teresa
DOI：
10.1039/c4tb00027g
发表时间：
2014-06-07
期刊：
Journal of materials chemistry. B
影响因子：
--
作者：
Levengood SL;Zhang M
通讯作者：
Zhang M