Neutrophil extracellular traps in cancer progression.
Neutrophil extracellular traps in cancer progression.
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DOI：
10.1007/s00018-014-1683-3
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发表时间：
2014-11
期刊：
影响因子：
--
通讯作者：
Ferri L
中科院分区：
文献类型：
--
作者：
Cools-Lartigue J;Spicer J;Najmeh S;Ferri L
中性粒细胞越来越被认为是肿瘤进展的重要因素。它们已被证明在肿瘤进展的几乎每个阶段都发挥着重要作用，许多研究表明它们的存在对肿瘤的发展至关重要。中性粒细胞生物学的新方面最近已被阐明，其对肿瘤发生的贡献才刚刚开始被认识到。中性粒细胞胞外陷阱(Net)是由DNA修饰抗菌肽形成的中性粒细胞衍生结构。它们已被证明能捕获和杀死微生物，在宿主防御中发挥关键作用。然而，它们对肿瘤的发展和转移的贡献最近在一些研究中得到证实，这些研究强调Net是一个潜在的重要治疗靶点。本文就Net作为肿瘤进展和转移促进剂的研究进展作一综述。此外，还探讨了NETS可能发挥这些作用的潜在机制。最后，强调了以Nets为靶点治疗人类肿瘤疾病的能力。
Neutrophils are being increasingly recognized as an important element in tumor progression. They have been shown to exert important effects at nearly every stage of tumor progression with a number of studies demonstrating that their presence is critical to tumor development. Novel aspects of neutrophil biology have recently been elucidated and its contribution to tumorigenesis is only beginning to be appreciated. Neutrophil extracellular traps (NETs) are neutrophil-derived structures composed of DNA decorated with antimicrobial peptides. They have been shown to trap and kill microorganisms, playing a critical role in host defense. However, their contribution to tumor development and metastasis has recently been demonstrated in a number of studies highlighting NETs as a potentially important therapeutic target. Here, studies implicating NETs as facilitators of tumor progression and metastasis are reviewed. In addition, potential mechanisms by which NETs may exert these effects are explored. Finally, the ability to target NETs therapeutically in human neoplastic disease is highlighted.
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作者：
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通讯作者：
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