Genomic insights into the fungal lignocellulolytic system of Myceliophthora thermophila.
Genomic insights into the fungal lignocellulolytic system of Myceliophthora thermophila.
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DOI：
10.3389/fmicb.2014.00281
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发表时间：
2014
影响因子：
5.2
通讯作者：
Christakopoulos P
中科院分区：
文献类型：
--
作者：
Karnaouri A;Topakas E;Antonopoulou I;Christakopoulos P
固体纤维素生物质向液体生物燃料的微生物转化可以为运输燃料提供可再生能源。纤维素分解真菌代表了一组有前途的生物体，因为它们已经进化出复杂的系统来适应它们的自然栖息地。丝状真菌嗜热毁丝霉（Myceliophthora thermophila）是一种非常强大的纤维素分解微生物，它能合成一整套分解植物细胞壁所必需的酶。该真菌的基因组最近已被测序和注释，允许系统检查和鉴定木质纤维素生物质降解所需的酶。基因组分析揭示了包括许多纤维素酶、半纤维素酶和具有辅助活性的酶的扩展的酶库的存在，覆盖了大多数公认的CAZy家族。其中大多数被预测为具有分泌信号并通过翻译后糖基化修饰。这些数据提供了一个更好的了解嵌入在真菌木质纤维素分解机制的活动，并建议M。嗜热菌可用作纤维素分解酶和半纤维素分解酶的工业生产宿主。
The microbial conversion of solid cellulosic biomass to liquid biofuels may provide a renewable energy source for transportation fuels. Cellulolytic fungi represent a promising group of organisms, as they have evolved complex systems for adaptation to their natural habitat. The filamentous fungus Myceliophthora thermophila constitutes an exceptionally powerful cellulolytic microorganism that synthesizes a complete set of enzymes necessary for the breakdown of plant cell wall. The genome of this fungus has been recently sequenced and annotated, allowing systematic examination and identification of enzymes required for the degradation of lignocellulosic biomass. The genomic analysis revealed the existence of an expanded enzymatic repertoire including numerous cellulases, hemicellulases, and enzymes with auxiliary activities, covering the most of the recognized CAZy families. Most of them were predicted to possess a secretion signal and undergo through post-translational glycosylation modifications. These data offer a better understanding of activities embedded in fungal lignocellulose decomposition mechanisms and suggest that M. thermophila could be made usable as an industrial production host for cellulolytic and hemicellulolytic enzymes.
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影响因子：
3.2
作者：
de Vries, RP;Poulsen, CH;Visser, J
通讯作者：
Visser, J
DOI：
10.1016/j.bbagen.2004.07.001
发表时间：
2004-11-01
影响因子：
3
作者：
Grishutin, SG;Gusakov, AV;Sinitsyn, AP
通讯作者：
Sinitsyn, AP
DOI：
10.1107/s0907444912042400
发表时间：
2013-01-01
影响因子：
2.2
作者：
Charavgi, Maria-Despoina;Dimarogona, Maria;Chrysina, Evangelia D.
通讯作者：
Chrysina, Evangelia D.
影响因子：
4.4
作者：
BHAT, KM;MAHESHWARI, R
通讯作者：
MAHESHWARI, R
DOI：
10.1111/j.1432-1033.1991.tb15984.x
发表时间：
1991-05-23
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
CANEVASCINI, G;BORER, P;DREYER, JL
通讯作者：
DREYER, JL