Impact of COVID-19 on the Endocrine System: A Mini-review.
Impact of COVID-19 on the Endocrine System: A Mini-review.
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DOI：
10.1210/endocr/bqab203
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发表时间：
2022-01-01
期刊：
影响因子：
4.8
通讯作者：
Dhillo WS
中科院分区：
文献类型：
--
作者：
Clarke SA;Abbara A;Dhillo WS
2019 年冠状病毒病 (COVID-19) 大流行继续对全球医疗保健系统产生重大影响，造成毁灭性的死亡率和发病率。随着时间的推移以及我们对这种新型呼吸道病毒了解的加深，越来越清楚的是，它的影响超出了呼吸系统的范围。导致 COVID-19 的冠状病毒（严重急性呼吸综合征冠状病毒 2）通过血管紧张素转换酶 2 (ACE2) 受体进入细胞，这一过程需要跨膜丝氨酸蛋白酶 2 (TMPRSS2) 蛋白。 ACE2和TMPRSS2在许多内分泌腺中广泛表达。再加上几例关于 COVID-19 患者甲状腺和垂体受损的病例报告，引起了人们对其对内分泌系统影响的极大兴趣。事实上，随着有效疫苗的日益普及而降低了死亡率，人们越来越关注 COVID-19 幸存者健康的长期影响。本综述总结了调查 COVID-19 对每个内分泌轴影响的数据，以指导适当的调查和最佳管理。
The coronavirus disease 2019 (COVID-19) pandemic continues to exert a significant impact on global health care systems, causing devastating mortality and morbidity. As time passes and our understanding of this novel respiratory virus deepens, it is increasingly clear that its effects extend beyond that of the respiratory system. The coronavirus responsible for COVID-19, severe acute respiratory syndrome coronavirus 2, obtains cellular access through the angiotensin-converting enzyme 2 (ACE2) receptor in a process requiring the transmembrane serine protease 2 (TMPRSS2) protein. Both ACE2 and TMPRSS2 are widely expressed in many endocrine glands. This, along with several case reports of thyroid and pituitary disruption in patients with COVID-19, has resulted in significant interest in its impact on the endocrine system. Indeed, as mortality is abated by the increasing availability of effective vaccines, there is increasing focus on the long-term effects on health in COVID-19 survivors. This review summarizes data investigating the effects of COVID-19 on each of the endocrine axes to guide appropriate investigations and optimal management.
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影响因子：
29
作者：
Coate KC;Cha J;Shrestha S;Wang W;Gonçalves LM;Almaça J;Kapp ME;Fasolino M;Morgan A;Dai C;Saunders DC;Bottino R;Aramandla R;Jenkins R;Stein R;Kaestner KH;Vahedi G;HPAP Consortium;Brissova M;Powers AC
通讯作者：
Powers AC
DOI：
10.1056/nejmoa1214969
发表时间：
2013-04-18
期刊：
The New England journal of medicine
影响因子：
--
作者：
Boonen E;Vervenne H;Meersseman P;Andrew R;Mortier L;Declercq PE;Vanwijngaerden YM;Spriet I;Wouters PJ;Vander Perre S;Langouche L;Vanhorebeek I;Walker BR;Van den Berghe G
通讯作者：
Van den Berghe G
影响因子：
5.8
作者：
Brancatella, Alessandro;Ricci, Debora;Latrofa, Francesco
通讯作者：
Latrofa, Francesco
影响因子：
2.3
作者：
Chen, Liao;Huang, Xin;Guo, Ruiqiang
通讯作者：
Guo, Ruiqiang
影响因子：
5.8
作者：
Bornstein, Stefan R.;Allolio, Bruno;Torpy, David J.
通讯作者：
Torpy, David J.