Neural Correlates of Attentional Processing of Threat in Youth with and without Anxiety Disorders.
Neural Correlates of Attentional Processing of Threat in Youth with and without Anxiety Disorders.
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DOI：
10.1007/s10802-018-0424-8
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发表时间：
2019-01
影响因子：
3.6
通讯作者：
Reeb-Sutherland BC
中科院分区：
文献类型：
--
作者：
Bechor M;Ramos ML;Crowley MJ;Silverman WK;Pettit JW;Reeb-Sutherland BC
通过事件相关电位（ERPs）量化的威胁性刺激的后期注意加工，可区分有焦虑症和无焦虑症的青年。目前尚不清楚是否早期阶段的注意处理威胁刺激区分这些群体。检查青少年早期和晚期的注意力过程可以促进知识的发展，并加强识别转化预防和治疗研究的生物标志物的努力。21名患有原发性DSM-IV-TR焦虑症的青少年（男性10名，年龄8-15岁）和21名正常发展的对照组（男性15名，年龄8-16岁）完成了点探针任务，同时记录了脑电图（EEG）并检测了erp。焦虑障碍青年在威胁性刺激下的P1波幅明显大于中性刺激，而对照组则相反。与对照组相比，焦虑青年表现出更大（更负）的N170振幅。与患有焦虑症的青少年相比，无论刺激效价如何，对照组的P2和P3波幅均显著增大（更正）。在点探测任务中观察到的erp表明，焦虑症青少年在早期注意定向和面孔加工中表现出明显的神经加工特征；但控制组的情况并非如此。这些结果表明，这些ERP成分可能有潜力作为青少年焦虑症的生物标志物。
Late-stage attentional processing of threatening stimuli, quantified through event-related potentials (ERPs), differentiates youth with and without anxiety disorders. It is unknown whether early-stage attentional processing of threatening stimuli differentiates these groups. Examining both early and late stage attentional processes in youth may advance knowledge and enhance efforts to identify biomarkers for translational prevention and treatment research. Twenty-one youth with primary DSM-IV-TR anxiety disorders (10 males, ages 8–15 years) and 21 typically developing Controls (15 males, ages 8–16 years) completed a dot probe task while electroencephalography (EEG) was recorded, and ERPs were examined. Youth with anxiety disorders showed significantly larger (more positive) P1 amplitudes for threatening stimuli than for neutral stimuli, and Controls showed the opposite pattern. Youth with anxiety showed larger (more negative) N170 amplitudes compared with Controls. Controls showed significantly larger (more positive) P2 and P3 amplitudes, regardless of stimuli valence, compared with youth with anxiety disorders. ERPs observed during the dot probe task indicate youth with anxiety disorders display distinct neural processing during early stage attentional orienting and processing of faces; this was not the case for Controls. Such results suggest these ERP components may have potential as biomarkers of anxiety disorders in youth.
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影响因子：
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